TCF7L2基因多态性与肥胖儿童青少年代谢的相关性研究  

Relationship between transcription factor 7-like 2 gene rs7903146 polymorphism and obesity in children and adolescents

作　　者：程若倩[1] 曹凌峰[2] 罗飞宏[1] 沈水仙[1] 陆炜[1] 杨毅[2] 叶蓉[1] 郑章乾[1] 章淼颖[1] 奚立[1] 支涤静[1] 

机构地区：[1]复旦大学附属儿科医院内分泌遗传代谢科,上海201102 [2]复旦大学附属儿科医院儿科研究所,上海201102

出　　处：《临床儿科杂志》2011年第12期1124-1128,共5页Journal of Clinical Pediatrics

摘　　要：目的探讨TCF7L2的基因单核苷酸多态性(SNP)rs7903146与肥胖儿童青少年代谢异常的相关性。方法701例3～18岁儿童青少年,根据体质指数(BMI)分为正常、肥胖、超重组,测定三酰甘油(TG)、总胆固醇(TCH)、空腹血糖(FPG)、空腹胰岛素(Fins),计算胰岛素抵抗指数(HOMA-IR)和定量胰岛素敏感指数(QUICKI),并研究TCF7L2基因SNP rs7903146在各组间的分布及不同基因型之间代谢指标的差异。结果正常组与肥胖/超重组间的等位基因频率差异无统计学意义(P=1.000),单核苷酸多态性与各项代谢指标之间无显著相关(P>0.05),不同基因型之间的空腹血糖异常、高脂血症、高胰岛素血症发生率差异无统计学意义(P>0.05),CC基因型HOMA-IR明显高于CT基因型(P=0.048),两者之间差异有统计学意义。结论 TCF7L2基因SNP rs7903146与肥胖儿童青少年的糖、脂代谢异常无明显相关,其基因型与胰岛素抵抗及胰岛素敏感性可能有关。Objective To study the association of the single nucleotide polymorphism（SNP）of TCF7L2 with the obese children and adolescents.Methods Subjects were divided into three groups：control,obese,and overweight group.Fasting Plasma Glucose（FPG）,Triglyceride（TG）,Total Cholesterol（TCH）and Fasting Insulin（Fins）were evaluated.Homeostasis Model of Assessment（HOMA-IR）and Quantitative Insulin Sensitivity Check Index（QUICKI）were calculated to evaluate the insulin resistance.The frequency of rs7903146 C/T genotype among different groups and its association with metabolic index were assessed.Results The frequency of allele C and T of SNP rs7903146 had no significant difference between obese/overweight groups and control group（χ2 0.001,P = 1.000）.No association were observed between SNP rs7903146 and metabolic changes（BMI、TG、TCH、FPG、Fins）.The level of HOMA-IR in CC genotype was significantly higher than that in CT genotype（F = 3.996,P = 0.046）.No significant association between SNP rs7903146 and the prevalence of hyperinsulinemia,hyperlipidemia and impaired FPG was found.Conclusions The SNP rs7903146 of TCF7L2 gene is associated with insulin resistance and not associated with metabolic changes.

关 键 词：肥胖 胰岛素抵抗 单核苷酸多态性 TCF7L2基因 儿童 

分 类 号：R589.2[医药卫生—内分泌]