绝经后骨质疏松症患者血清NO-iNOS系统及相关激素水平变化的探讨  

Changes of Serum NO-iNOS System and Associated Hormone Levels in Patients with Postmenopausal Osteoporosis

作　　者：郑青[1] 陈寒超[1] 

机构地区：[1]海口市人民医院检验科,海南海口570208

出　　处：《标记免疫分析与临床》2011年第6期380-382,共3页Labeled Immunoassays and Clinical Medicine

摘　　要：观察绝经后骨质疏松症(PMO)患者NO、诱导型一氧化氮合酶(iNOS)及E2、GH、PTH、25(OH)D3等相关激素,探讨NO-iNOS系统及相关激素在骨质疏松发病机制中的作用和意义。80例绝经1年以上女性,根据扫描骨密度(BMD),Tscore值,分为骨质疏松组(OP组)34例,非骨质疏松组(NOP组)46例,及绝经前女性为对照组38例。用硝酸还原酶法测NO,分光光度法测iNOS,CLIA法测血清E2、GH、PTH水平,ECLIA法测25(OH)D3。结果显示,绝经后女性NO、iNOS、E2、GH、25(OH)D3水平显著降低,OP组又低于NOP组;PTH水平无明显改变。PMO患者骨丢失是骨转换加快和重建负平衡骨吸收超过骨形成所致,NO-iNOS系统与雌激素、GH参与PMO的病理生理过程。To observer the changes of NO,inducible nitric oxide synthase（iNOS） and E2,GH,PTH,25（OH） D3 in postmenopausal osteoporosis（PMO） patients,to explore the role and significance of NO-i NOS system and other related hormone in PMO.The 80 patients women with menopause over 1 year based on bone mineral density（BMD）,Tscore value were divided into osteoporosis group with 34 cases（OP group）,non-osteoporosis group with 46 cases（NOP group）,and the 38 premenopausal women were selected the control group.The serum levels of NO were detected by nitrate reductase enzymatic and iNOS by spectrophotometry,and the serum levels of E2,GH,and PTH were determined by CLIA,and the serum 25（OH） D3 was detected by ECLIA.The results showed that the serum NO,iNOS,E2,GH,25（OH） D3 levels in PMO women were significantly decreased and were lower in OP group than that of in NOP group;The PTH levels did not significantly change.PMO bone loss was due to the bone turnover accelerated（high conversion type） and the reconstruction of negative balance of bone absorption exceeds bone formation.NO-iNOS system,and E2,GH were participated in the pathophysiology process of PMO.

关 键 词：绝经后骨质疏松症 一氧化氮 诱导型一氧化氮合酶 雌二醇 生长激素 扫描骨密度 

分 类 号：R580[医药卫生—内分泌]