乙酰丙酮酸乙酯的合成  

Synthesis of Ethyl acetopyruvate

作　　者：曾海霞 赵煜松 

机构地区：[1]河北省医疗器械与药品包装材料检验所,河北石家庄050061

出　　处：《河北化工》2011年第12期30-31,34,共3页Hebei Chemical Industry

摘　　要：乙酰丙酮酸乙酯作为重要的有机合成中间体,主要通过克莱森缩合反应来制备。由草酸二乙酯、丙酮、乙醇、金属钠合成乙酰丙酮酸乙酯。研究了其主要副反应,分析了影响产率的因素。结果表明,该工艺适合工业化生产。Ethyl acetopyruvate,an important intermediate for organic synthesis,is mainly prepared through the Claisen condensation reaction.It was synthesized by diethyl oxalate,acetone,ethanol and sodium.The major side effects were studied.This process is suitable for industrial production.

关 键 词：乙酰丙酮酸乙酯 草酸二乙酯 合成 克莱森缩合 加成 消除 

分 类 号：TQ225.242[化学工程—有机化工]