^(131)I治疗对SD大鼠血清降钙素水平的影响  

Influence of ^(131)I Internal Radiation on the Levels of Serum Calcitonin in SD Rats

作　　者：殷艳海[1] 赵明[1] 童良前[1] 韩云峰[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院核医学科,湖北武汉430030

出　　处：《同位素》2011年第4期225-228,共4页Journal of Isotopes

摘　　要：为了研究SD大鼠甲状腺经不同剂量131I内照射后,短期内C细胞损伤情况及对大鼠血清降钙素(cal-citonin,CT)水平和CT储备功能的影响,将30只SD大鼠随机分成对照组、小剂量组、大剂量组,分别测定给Na131I前及给Na131I一月后血清降钙素水平,并通过钙负荷-降钙素释放试验测定降钙素储备功能。结果显示:给Na131I后小剂量组和大剂量组CT基础值、经钙负荷后降钙素峰值、升高幅度均明显降低,与给药前有显著差异(P<0.05)。且不同剂量间CT基础值、降钙素峰值及升高幅度均有显著性差异。甲状腺组织CT免疫组化染色结果显示,照射后C细胞数量及分布密度明显降低。因此认为,131I治疗后大鼠血清CT水平减低,CT储备功能下降,其减低程度与131I剂量有相关性。Research was performed to evaluate the short-term injury of thyrod C cells and the changes of serum calcitonin level and calcitonin reserve function in SD rats after the exposure to different doses of ^131I. Thirty SD rats were randomly divided into three groups： a control group, a low-dose group and a high-dose group. The serum calcitonin levels and calcitonin reserve function of all the rats were measured before and a month after receiving NaTMI. The thyroids were then taken for H-E staining and calcitonin immunohistochemical staining after the rats were sacrificed. The experimental data showed that, for both the low-dose group and high-dose group, the base values, peak values and the degree of increase in serum calcitonin all decreased significantly after receiving ^131I, in comparison with those values before receiving ^131I （P〈0.05）. Besides, there was significant difference in the data among the three groups （P〈0.05）. Significant decrease in the number and distribution density of C cells in the thyroids of the rats after receiving ^131I was also observed in calcitonin immunohistochemical staining. All these results demonstrated that both the level of serum calcitonin and the calcitonin reserve function decreased after receiving ^131I radiation and the degree of the decrease was related to the dose of ^131I.

关 键 词：131I 血清降钙素 降钙素储备功能 C细胞 

分 类 号：R817.5[医药卫生—影像医学与核医学]