贝那普利单用及其与乐卡地平联用的临床疗效及安全性观察  

Efficacy and safety of benazepril alone or in combination with lercanidipine

作　　者：肖洁[1] 赵秀丽[1] 周辉[1] 郭韶洁[1] 武峰[1] 王淑民[1] 

机构地区：[1]首都医科大学附属北京同仁医院,北京100730

出　　处：《世界临床药物》2011年第12期731-734,共4页World Clinical Drug

摘　　要：目的评估贝那普利单用及其与乐卡地平联用治疗原发性轻中度高血压的疗效和安全性。方法入选本研究的原发性轻中度高血压患者138例,经4周贝那普利10 mg单药治疗后坐位舒张压(SeDBP)≥90 mmHg的患者89例,随机分为贝那普利10 mg联合乐卡地平10 mg治疗(A组)和贝那普利20 mg单药治疗(B组),治疗4周,SeDBP仍≥90 mmHg的患者治疗剂量加倍,其余维持原剂量,均继续治疗4周。结果治疗第8周A组平均血压水平比B组低(P<0.05)。治疗第4、8周时,A组血压达标率均优于B组,两组血压达标率第4周分别为76.2%和60.1%(P<0.05),第8周分别为88.1%和67.4%(P<0.05)。两组不良事件发生率差异无统计学意义。结论贝那普利联用乐卡地平治疗原发性轻中度高血压,可提高血压达标率,同时患者耐受性好,两者联合安全有效。Objective To observe the efficacy and safety of benazepril alone or in combination with lercanidipine in patients with mild to moderate essential hypertension. Methods Among 138 patients with mild to moderate essential hypertention treated with benazepril 10 mg/d for 4 weeks, 89 patients with seated diastolic blood pressure （SeDBP） remained≥90 mmHg were randomly divided to group A （benazepril 10 mg, lercanidipine 10 mg） and group B （benazepril 20 mg）. At the end of 4 weeks, patients with SeDBP ≥ 90mmHg were doubled the dosage of the initial regimen for additional 4 weeks, and the patients with SeDBP〈90 mmHg remained the initial regimen to 4 weeks. Results The blood pressure in group A was lower than that in group B at the end of 8 weeks （P〈0.05）. Compared with group B, the reaching target blood pressure rate in group A was better at the end of 4 and 8 weeks （76.2% vs 60.1%, P〈0.05; 88.1% vs 67.4%, P 〈0.05）. There was no significant difference in adverse reaction between both groups. Conclusion Benazepril combined with lercanidipine for mild to moderate essential hypertension patients is effective in improving blood pressure, and the patients are well tolerated.

关 键 词：贝那普利 乐卡地平 高血压 联合治疗 

分 类 号：R969.4[医药卫生—药理学] R972.4[医药卫生—药学]