乳腺癌患者的甲状腺功能研究  

Thyroid function in patients with breast cancer

作　　者：梅怡[1] 冯雯[1] 奉典旭[1] 

机构地区：[1]上海中医药大学附属普陀医院普外科,上海200062

出　　处：《世界临床药物》2011年第12期735-737,741,共4页World Clinical Drug

摘　　要：目的探讨甲状腺功能与乳腺癌的关系。方法收集2009年1月至2011年3月我院诊治的乳腺癌病例68例、乳腺良性疾患111例,正常对照病例45例。以直接化学发光法检测血清FT_3、FT_4、TSH-3、aTG、aTPO水平。结果乳腺癌组患者血清FT4水平(16.32±3.32)和aTPO水平(51.30±39.14)虽均在正常范围,但其FT4水平显著低于乳腺良性疾病组和正常对照组(P<0.01),其aTPO水平高于乳腺良性疾病组和正常对照组(P<0.05)。结论甲状腺功能和乳腺癌的发生发展有一定联系,甲状腺激素和自身抗体水平有助于临床监测和预后判断。Objective To explore the relationship between thyroid function and breast cancer. Methods Breast cancer patients（n=68）, benign breast diseases （n=111）, and healthy controls （n=45） in our hospital from Jan, 2009 to Mar, 2011 were included in the study. The levels of thyroid hormones （FT4, FT3, TSH-3） and the levels of thyroid antibodies （aTPO and aTG） were determined by direct RIA in serum. Statistical analysis was performed by Independent Samples T-Test. （P〈0.05）. Results Although in breast cancer patients the levels of FT4（16.32±3.32） and the levels of aTPO （51.30± 39.14）were in the normal range, but the levels of FT4 were lower and the levels of aTPO were higher than those in patients with benign breast diseases or healthy controls respectively （P〈0.05）. Conclusion Thyroid function is associated with the growth and progression of human breast cancer. These data suggest that thyroid hormone and thyroid autoantibodies are significant in clinical monitoring or predicting the prognosis of breast carcinoma.

关 键 词：乳腺癌 甲状腺功能 抗甲状腺自身抗体 

分 类 号：R937.9[医药卫生—生药学] R730.231.4[医药卫生—药学]