LM23 may regulate the G1/S and G2/M transitions of the cell cycle in rat spermatogenesis  

作　　者：成毅明 刘美玲 詹皓 成玉 贾孟春 

机构地区：[1]Air Force Institute of Aviation Medicine [2]Department of Reproductive Endocrinology,National Research Institute for Family Planning [3]Department of Dermatology,The General Hospital of the Air Force

出　　处：《生殖医学杂志》2011年第B12期51-56,共6页Journal of Reproductive Medicine

基　　金：supported by the National Natural Science Foun dation of China(No.81170616)

摘　　要：Objective:LM23（AF492385） is a gene specifically expressed in the testis of Rattus norvegicus previously reported by our laboratory.The aim of the study is to further investigate its biological function. Methods:Bioinformatic tools were utilized,including Protfun server and CPHmodles.The biological functions of LM23 were analyzed with microarray analysis,using a rat model of LM23 gene knock-down. Results:Protfun server shows that LM23 is likely a growth factor or Lyase.LM23 is more likely involved in regulatory functions of translation.The expressions of some genes related to the cell cycle were significantly changed after LM23 knock-down,as shown by microarray analysis. Conclusions:LM23 may regulate the G1/S and G2/M transitions of the cell cycle during spermatogenesis.Objective： LM23 （AF492385） is a gene specifically expressed in the testis of Rattus norvegicus previously reported by our laboratory. The aim of the study is to further investigate its biological function. Methods： Bioinformatic tools were utilized, including Protfun server and CPHmodles. The biological functions of LM23 were analyzed with microarray analysis, using a rat model of LM23 gene knock-down. Results： Protfun server shows that LM23 is likely a growth factor or Lyase. LM23 is more likely involved in regulatory functions of translation. The expressions of some genes related to the cell cycle were significantly changed after LM23 knock-down, as shown by microarray analysis. Conclusions： LM23 may regulate the G1/S and G2/M transitions of the cell cycle during spermatogenesis.

关 键 词：精子发生过程 细胞周期 大鼠模型 G2 S期 生物学功能 基因敲除 基因芯片 

分 类 号：Q253[生物学—细胞生物学] S814.1[农业科学—畜牧学]