肌酸激酶同工酶对围产期窒息程度和短期预后的预测价值  

Value of creatine kinase isoenzyme in predicting severity and short term prognosis of perinatal asphyxia

作　　者：谢露[1] 陈洪清[2] 杨尧[2] 郑天[2] 尹晓娟[1,2] 

机构地区：[1]安徽医科大学北京军区总医院临床学院,合肥230032 [2]北京军区总医院附属八一儿童医院新生儿科,北京100700

出　　处：《中国优生与遗传杂志》2012年第1期50-52,57,共4页Chinese Journal of Birth Health & Heredity

摘　　要：目的评估血清肌酸激酶同工酶(CK-MB)的变化与围产期窒息程度及短期预后的相关性。方法采用前瞻性序贯试验研究方案,随机选择245例足月新生儿为研究对象,比较142例窒息新生儿和103例正常新生儿血清CK-MB水平差异,评估CK-MB与围产期窒息严重度指标1min Apgar评分、脐动脉血pH及其短期预后的相关性。结果窒息组CK-MB水平显著高于正常对照组,差异比较有统计学意义(P<0.001)。CK-MB与围产期窒息严重度指标1min Ap-gar评分和脐动脉血pH呈负相关(P<0.001),与围产期窒息短期不利预后呈正相关(P<0.001)。结论血清CK-MB有助于早期预测围产期窒息程度和短期预后。Objective： Perinatal asphyxia is a major cause of neurologic morbidity and mortality.The purpose of this study was to investigate variations in serum creatine kinase isoenzymes（CK-MB） associated with perinatal asphyxia and its relationship to both the severity and short term prognosis of asphyxia.Methods： The prospective sequential trial design was conducted on 245 selected randomly term infants.Levels of serum CK-MB were compared for 142 asphyxiated（case group） and 103 normal neonates（control group）.These parameters were also related to the severity of asphyxia and clinical short-term outcome.Results： The levels of serum CK-MB in the case group were significantly greater than the corresponding values in the controls（P0.001）.A statistically significant negative correlation existed between CK-MB and indicators of the severity of perinatal asphyxia,first minute Apgar score and umbilical arterial pH（P0.001）,respectively.A positive correlation was demonstrated between these parameters and poor outcome（P0.001）.Conclusions： Serum CK-MB is a useful predictor of severity and short-term outcome of perinatal asphyxia.

关 键 词：围产期窒息 缺氧缺血性脑病 肌酸激酶同工酶 预后 

分 类 号：R722.1[医药卫生—儿科]