骨质疏松对骨折愈合的相关研究  

The effects of senile osteoporosis on fracture healing

作　　者：韩建波[1] 陈猛[1] 李树锋[1] 

机构地区：[1]山东省千佛山医院骨科,济南250014

出　　处：《中国综合临床》2011年第12期1308-1310,共3页Clinical Medicine of China

摘　　要：目的探讨骨质疏松患者骨折的风险及抗骨质疏松治疗对骨折愈合的影响。方法2006年8月至2011年2月收治老年下肢骨折患者15例，年龄53．0～65．0岁，平均56．7岁。经手术复位内固定术，术后均采用免负重功能练习，辅助关节功能训练机（CPM）功能锻炼并抗骨质疏松治疗。术前、术后均拍摄腰椎及骨折部位的x线片、行骨密度测量、检测血钙和血磷变化。结果15例患者中有13例在治疗3个月后，骨折线模糊，达到骨折临床愈合标准，临床骨折愈合率达86．67％。血钙、血磷及骨密度测定，治疗前后比较差异均有统计学意义[血钙治疗前、后分别为：（2．24±0．25）、（3．31±0．35）mmol/L，t=-11．469，P〈0．05；血磷治疗前、后分别为（0．86±0．21）、（1．28±0．23）mmol／L，t=-6．514，P〈0．05；骨密度治疗前、后分别为-3．60±0．14、-1．10±0．16，t=-36．654，P〈0．05]。结论骨质疏松症不但增加骨折的风险，还对骨折的愈合有着不利的影响。抗骨质疏松治疗对老年患者骨折愈合有积极作用。Objective To explore the fraction risk in patients with osteoporosis and effects of antiosteoporosis therapy on fracture healing. Methods All the recruited subjects were senile patients with fracture in lower extremity and were treated in the Department of Orthopaedics in Shandong Qianfoshan Hospital from Aug. 2006 to Feb. 2011. In the total 15 cases, 10 were female and 5 were male, aged from 53 to 65 years （average 56. 7 years old）. After surgical reduction and internal fixation, all the 15 patients did free-weight and continous passive motion （CPM） functional exercise and received anti-osteoporosis treatment. X-ray was taken to show the preoperative and postoperative lumbar vertebrae and fracture position. Meanwhile, bone mineral density and blood calcium level and phosphate level were measured. Results Thirteen out of 15 patients were healed for bone fracture after a 3-month treatment, meeting the clinical standards of the fracture healing. The clinical fracture healing rate was 86. 67%. Blood calcium level, phosphate level and the bone mineral density were significantly different between that before and after the treatment （ P 〈 0. 05 ）. Conclusion Osteoporosis not only increases the risk of fracture, but also has an adverse effect on the bone healing. Anti-osteoporosis therapy has a positive role to the fracture healing in the senile patients with osteoporosis.

关 键 词：骨质疏松症 骨折 抗骨质疏松药 骨密度 血钙 血磷 

分 类 号：R580[医药卫生—内分泌]