变异链球菌的VicRK双组分信号传导系统  

VicRK two-component signal transduction system of Streptococcus mutans

作　　者：田媛媛[1] 胡涛[1] 

机构地区：[1]口腔疾病研究国家重点实验室四川大学,成都610041

出　　处：《国际口腔医学杂志》2012年第1期89-92,共4页International Journal of Stomatology

基　　金：国家自然科学基金资助项目(81041104)

摘　　要：变异链球菌是人类龋病的主要病原菌,它通过蔗糖依赖性黏附形成生物膜并在其中产酸耐酸,最终导致龋病。VicRK是变异链球菌13种双组分信号传导系统之一,可调节变异链球菌致龋性毒力相关因子的表达。本文就VicRK的作用机制、结构组成、生理特性,及其对变异链球菌致龋性的影响,VicRK和VicX间的关系等研究进展作一综述。Streptococcus mutans （S.mutans）, which is considered as the chief pathogen of human caries, possesses the ability to form biofilm via sucrose-dependent adhesion, genesis and endure acids in the biofilm that may ultimately lead to dental caries. VicRK is one of the 13 putative two-component signal transduction systems of S.mutans that modulate the expression of cariogeneisis related virulence factors. This review summarized the mechanism, structural organization, physiological characteristics and the impact on the cariogenesis capabilities of Vi- cRK, as well as the correlation between VicRK and VicX in S.mutans.

关 键 词：变异链球菌 双组分信号传导系统 基因表达 VicRK 

分 类 号：R378[医药卫生—病原生物学]