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机构地区:[1]南京军区杭州疗养院检验科,浙江杭州310007
出 处:《中国热带医学》2011年第11期1336-1337,1356,共3页China Tropical Medicine
摘 要:目的研究浙江省部分人群乙肝病毒(HBV)感染与代谢综合征的相关性以及MS的危险因素分析。方法在体检人群中选择丙型肝炎抗体阴性的7774例受检者,分别测量身高、体重、血压、血脂、血糖、肝酶、胰岛素和乙肝标志物等指标。结果 HBsAg阳性检出率8.31%(646例),男性HBsAg阳性组中的ALT、AST、GGT、胰岛素(IRI),HOMA-IR和HOMA-β均高于男性HBsAg阴性组(P<0.01,P<0.05);男性HBsAg阳性组中的TG、TC、UA均显著低于对照组(P<0.05);在女性HBsAg阳性组中仅ALT与对照组有差异(P<0.05);MS发病率为10.13%,男性HBsAg阳性组MS发病率低于男性HBsAg阴性组(11.5%vs 16.67%,P<0.05);女性HBsAg阳性组MS的发病率为4.20%(9/214);女性HBsAg阴性组MS发病率为3.75%,女性组之间没有差异(P>0.05)。患MS的危险因素分别有体重指数(BMI)、年龄、性别、血清胰岛素、TC、TG、UA以及胰岛素抵抗指数(HOMA-IR)。结论 HBsAg感染与MS发病率无相关性,但是与胰岛素抵抗相关。Objiectie To analyze the relationship between hepatitis B virus infection and metabolic syndrome incidence in partial population of Zhejiang.Methods A total of 7 774 subjects negative for HBcAb were selected and the body height,body height,blood pressure,biochemistry items of them were measured.Results The positive rate HBsAg was 8.31%.The ALT,AST,GGT,IRI,HOMA-IR and HOMA-β in male HBsAg positive group were higher than that of the male HBsAg negative group(P0.01,P0.05)and The TG,TC and UA in male HBsAg positive group were lower than that of the male HBsAg negative group(P0.05).The prevalence of MS was 10.13%.The prevalence of MS in male HBsAg positive group were lower than that of the male HBsAg negative group(11.5% vs 16.67%,P0.05);The prevalence of MS in female HBsAg positive group was 4.2%.The prevalence of MS in female HBsAg negative group was 3.75%.There was no significant difference between the female groups(P0.05).Logistic regression analysis demonstrated that the parameters of increased BMI,age,sex,serum insulin,TC,UA and HOMA-IR were significantly associated with MS.Conclusion HBsAg infection was not associated with MS incidence but correlated with insulin resisitance(IR).
分 类 号:R373.21[医药卫生—病原生物学]
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