走马胎化学成分研究  

Study on chemical constituents of rhizome of Ardisia gigantifolia

作　　者：封聚强[1,2] 黄志雄[1,2] 穆丽华[1] 赵海霞[1] 刘屏[1] 

机构地区：[1]解放军总医院临床药理研究室,北京100853 [2]天津中医药大学,天津300193

出　　处：《中国中药杂志》2011年第24期3463-3466,共4页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(31000153)

摘　　要：目的:对紫金牛科紫金牛属植物走马胎干燥根茎进行化学成分研究。方法:对走马胎根茎乙酸乙酯提取物进行各种柱色谱分离,根据所得化合物的波谱数据鉴定结构。结果:分离鉴定了9个化合物,分别鉴定为11-O-galloylbergenin(1),11-O-syringylbergenin(2),11-O-protocatechuoylbergenin(3),4-O-galloylbergenin(4),11-O-香草酰岩白菜素(5),表儿茶素-3-没食子酸酯(6),豆甾醇-3-O-β-D-吡喃葡萄糖苷(7),(-)-4'-hydroxy-3'-methoxyphenyl-β-D-[6-O-(4″-hydroxy-3″,5″-dimethoxy-benzoyl)]-glucopyranoside(8),β-谷甾醇(9)。结论:化合物3,4,7为首次从该属植物中分离得到,化合物1,2,5,6为首次从该种植物中分离得到。Objective： To study the chemical constituents of the dried rhizome of Ardisia gigantifolia.Method： The 60% ethanol extract was extracted with EtOAc,and then separated and purified by column chromatography using silica gel and preparative HPLC.Their structures were identified on the basis of spectral analysis and physico-chemical properties.Result： Nine compounds were isolated and identified as 11-O-galloylbergenin（1）,11-O-syringylbergenin（2）,11-O-protocatechuoylbergenin（3）,4-O-galloylbergenin（4）,11-O-vanilloylbergenin（5）,（-）-epicatechin-3-gallate（6）,stigmasterol-3-O-β-D-glucopyranoside（7）,（-）-4′-hydroxy-3＇-methoxyphenyl-β-D-[6-O-（4″-hydroxy-3″,5″-dimethoxybenzoyl）]-glucopyranoside（8）,and β-sitosterol（9）.Conclusion： Compounds 3,4 and 7 were isolsted from the genus Ardisia for the first time,while compounds 1,2,5 and 6 were isolated from this plant for the first time.

关 键 词：走马胎 化学成分 

分 类 号：R284[医药卫生—中药学]