凉血通瘀方治疗出血性中风急性期瘀热阻窍证患者73例临床观察  

Clinical Observation on Liangxue Tongyu Formula Combined with Western Medicine for Acute Hemorrhagic Stroke with the TCM Syndrome of Stasis-Heat Obstructing in the Brain:a Report on 73 Cases

作　　者：张兰坤[1,2] 过伟峰[3] 徐丹[1] 袁园[3] 李建香[4] 马慧敏 张红新 

机构地区：[1]南京中医药大学第一临床医学院 [2]南京中医药大学第二附属医院神经内科 [3]南京中医药大学 [4]南京市中医院 [5]河南省中牟县人民医院 [6]江苏省张家港市中医医院

出　　处：《中医杂志》2012年第1期28-30,44,共4页Journal of Traditional Chinese Medicine

基　　金：国家重点基础研究发展计划("973"计划)资助项目(2006CB504807)

摘　　要：目的评价凉血通瘀方治疗出血性中风急性期瘀热阻窍证的临床疗效。方法将135例患者随机分为治疗组73例和对照组62例,两组均采用西医内科常规治疗,治疗组同时服用凉血通瘀方,疗程均为21天。疗程结束后统计并比较两组中风病类诊断评分、瘀热阻窍证候积分、综合疗效及脑出血量情况。结果治疗后两组中风病类诊断评分均明显下降,与治疗前比较差异有统计学意义(P<0.01);治疗组治疗后评分明显低于对照组(P<0.05),治疗前后差值明显大于对照组(P<0.01)。两组患者治疗后11天、21天瘀热阻窍证候评分及脑出血量均较治疗前明显下降(P<0.01),治疗后21天与11天比较,证候评分及脑出血量亦明显下降(P<0.01);治疗后21天,两组瘀热阻窍证候评分及脑出血量比较,治疗组明显低于对照组(P<0.01)。治疗组总有效率93.1%,对照组总有效率77.4%,两组比较差异具有统计学意义(P<0.01)。结论凉血通瘀方治疗出血性中风急性期瘀热阻窍证能显著提高疗效,降低中风病类诊断评分及瘀热阻窍证候评分,促进脑出血吸收。Objective To evaluate the effect of Liangxue Tongyu Formula （Formula to cool blood and remove stasis） in the treatment of the TCM syndrome of stasis-heat obstructing in the brain in the acute hemorrhagic stroke. Methods Totally 135 cases were randomized into treatment group, 73 cases, and control group, 62 cases. Both groups were treated with the routine medication of western medicine, and the treatment group was administered Liangxue Tongyu Formula additionally. The course of treatment for the two groups was 21 days. Then, their scores of stoke diagnosis, scores of syndrome of stasis-heat obstructing in the brain, comprehensive effect, and cerebral hemorrhage were compared. Results After treatment, the scores of stoke diagnosis of the two groups were both significantly lowered significantly （both P〈0.01） ; the score of the treatment group was significantly lower than that of the control group （P〈0.05）, and the difference between before and after treatment was signifi- cantly bigger than that of the control group （P〈0.01）. After treatment of 11 and 21 days, the scores of syndrome hemorrhage of the two groups were both significantly lowered compared with before treatment （P〈0.01）, and the scores and hemorrhage after 21 days were also significantly reduced compared with that after 11 days （P〈0.01）. After treatment for 21 days, the score of syndrome and hemorrhage of the treatment group was significantly less than those of the control group （P〈0.01）. The total effective rate of the treatment group and the control group was 93.1 % and 77.4 % respectively, and the difference was significant （P〈0.01）. Conclusion Liangxue Tongyu Formula could significantly improve the therapeutic effect of the syndrome of stasis-heat obstructing in the brain in the acute hemorrhagic stroke patients, lowering the score of stoke diagnosis and the score of syndrome, and promoting the haematoma absorption.

关 键 词：出血性中风 急性期 瘀热阻窍证 凉血通瘀方 疗效评价 

分 类 号：R255.2[医药卫生—中医内科学]