Th17细胞及其相关细胞因子与支气管哮喘  

Advance on studies of T helper 17 cells and its relative cytokines and bronchial asthma

作　　者：安霞[1] 龚颖[1] 叶伶[1] 金美玲[1] 

机构地区：[1]复旦大学附属中山医院呼吸科,上海200032

出　　处：《国际呼吸杂志》2012年第1期43-46,共4页International Journal of Respiration

基　　金：上海市重点学科建设项目资助（B115）;复旦大学新教师科研启动基金（10FX088）

摘　　要：Th17细胞是一种独立的Th细胞亚群。近年来研究表明其在支气管哮喘的发病中发挥着重要作用。一系列细胞因子参与了针对Th17细胞的调控。这其中转化生长因子β1、白介素6（IL-6）是Th17细胞分化的启动因子；IL-23是分化的促进因子；7干扰素、IL-4则是分化的抑制因子。Th17细胞分泌的特征性细胞因子IL-17加重了气道炎症，参与了气道重塑。T helper 17 cells is a kind of independent Th lymphocyte subsets. Recent studies show that it plays an important role in the pathogenesis of bronchial asthma. A series of cytokines involved in the regulations of Th17 cells. Among them, TGF-beta 1 and IL-6 are initiators in the differentiation of Thl7 cells,IL-23 is a promoting factor in the differentiation, IFN-gamma and IL-4 are inhibitory factors. IL-17, as the characteristic cytokine secreted by Th17 cells, can increase airway inflammation and participate in the airway remodeling.

关 键 词：TH17细胞 白介素17 哮喘 

分 类 号：R562.25[医药卫生—呼吸系统]