参草通脉颗粒对心衰大鼠双向调节药效学研究  

Pharmacodynamics Study of Bidirectional Regulation of Shencao Tongmai Granules to Rats with CHF

作　　者：曲颂扬[1] 张艳[1] 王辰[1] 刘晓蕾[2] 礼海[3] 

机构地区：[1]辽宁中医药大学附属医院,辽宁沈阳110032 [2]辽宁中医药大学,辽宁沈阳110847 [3]沈阳市第二中医医院,辽宁沈阳110101

出　　处：《辽宁中医药大学学报》2012年第1期194-196,共3页Journal of Liaoning University of Traditional Chinese Medicine

摘　　要：参草通脉颗粒是临床治疗慢性心衰的经验方,用于防治慢性心衰已取得较好的疗效。通过观察参草通脉颗粒对慢性心衰大鼠心肌基质金属蛋白酶-1(MMP-1)和基质金属蛋白酶特异性抑制物-1(TIMP-1)的双向调节作用。研究中药对慢性心衰的药效学作用和作用靶点,为中医药防治慢性心衰提供客观依据。Shencao Tongmai granule, as the most commonly-used fomula based on medical experience, has a good therapeutic effect on the treatment of patients with CHF. On observing the bidirectional regulation of Shencao Tongmai granule to matrix metall oproteinases and tissue inhibitor, the TCM pharmacodynamics and the eutherapeutic target on CHF were studied, providing objective evidence for clinical treatment.

关 键 词：慢性心衰 双向调节 药效学 

分 类 号：R285.5[医药卫生—中药学]