长期使用抗精神病药对精神分裂症患者认知功能的影响研究  

Study on the Effects of Long-term Treatment with Antipsychotics on Cognitive Function of Schizophrenia Patients

作　　者：胡耀祖[1] 

机构地区：[1]佛山市第三人民医院,广东佛山528000

出　　处：《中国药房》2012年第2期168-170,共3页China Pharmacy

摘　　要：目的:探讨长期使用典型和非典型抗精神病药对精神分裂症患者认知功能的影响。方法:对45例持续服用典型或非典型抗精神病药10年以上的精神分裂症患者,使用蒙特利尔认知评估量表(MoCA)、简易智能精神状态量表(MMSE)和简明精神病评定量表(BPRS)检测患者目前的认知功能和精神症状。结果:典型和非典型抗精神病药或两型药物联用患者之间的MoCA、MMSE、BPRS差异不显著。结论:长期治疗的精神分裂症患者,认知功能损害与药物因素的相关性不明显,可能与疾病的结局相关。MoCA可作为非急性期精神分裂症患者认知功能的评定工具。OBJECTIVE： To explore the influence of long-term use of typical and atypical antipsychotics on cognitive function in schizophrenia patients. METHODS： 45 patients with schizophrenia using typical or atypical antipsychotics for above 10 years were determined in respects of cognitive state and mental symptom with Montreal cognitive assessment （MoCA）and mini-mental state examination （MMSE） and brief psychiatric rating scale （BPRS）. RESULTS： Typical and atypical antipsychotics or combined use of them had no significant difference in MoCA, MMSE and BPRS. CONCLUSION： For schizophrenia patients receiving long-term treatment, cognitive function impairment has no obvious relationship with drugs. It may be associated with disease outcomes. MoCA can be used as an evaluation tool for cognitive function of patients with schizophrenia in un-acute period.

关 键 词：抗精神病药 认知功能 精神分裂症 蒙特利尔认知评估量表 

分 类 号：R971.4[医药卫生—药品]