超敏-C反应蛋白及同型半胱氨酸内皮素检测对冠心病患者的诊断价值  

CLINICAL VALUE OF THE CONTENT OF HIGH SENSITIVE C-REACTIVE PROTEIN AND PLASMA HOMOCYSTEINE AND ENDOTHELIN IN PATIENTS WITH CORONARY HEART DISEASE

作　　者：初开秋[1] 张少燕[1] 杨爱华[1] 任立晟[1] 谭丽娟[2] 

机构地区：[1]青岛大学医学院附属医院检验科,青岛266003 [2]青岛大学医学院附属医院心血管内科

出　　处：《现代预防医学》2012年第1期230-231,233,共3页Modern Preventive Medicine

摘　　要：[目的]探讨冠心病患者超敏-C反应蛋白、同型半胱氨酸及内皮素水平变化的相关性。[方法]对56例冠心病患者组和46例健康对照组分别采用高效液相色谱分析法和放射免疫分析法,测定血浆中同型半胱氨酸水平和内皮素水平,同时测定血清中超敏-C反应蛋白含量。[结果]冠心病组超敏-C反应蛋白(9.70±2.37)mg/L、同型半胱氨酸(20.82±6.61)μmol/L、内皮素(83.51±14.47)ng/L,明显高于对照组超敏-C反应蛋白(0.96±0.44)mg/L、同型半胱氨酸(9.35±2.60)μmol/L、内皮素(48.57±15.64)ng/L(P均﹤0.001),超敏-C反应蛋白、同型半胱氨酸与内皮素呈正相关(r=0.731,P﹤0.01;r=0.532,P﹤0.01)。[结论冠心病患者超敏-C反应蛋白含量、同型半胱氨酸及内皮素水平显著增高,可能与动脉粥样硬化的发生发展有关。[Objective]To investigate the role and correlation in changes of the content of high sensitive C-reactive protein（hsCRP）and homocysteine（Hcy）,endothelin（ET）in patients with coronary atherosclerosis.[Methods]Hcy,ET and hsCRP of 56 cases with coronary heart disease（CHD）and 46 normal persons as controls were detected respectively by high-performance liquid chromatography and radioimmunoassay.[Results]In CHD patients,the level of hsCRP（9.70±2.37）mg/L Hcy（20.82±6.61）μmol/L,ET（83.51±14.47）ng/L were significantly higher than those of controls（0.96±0.44）mg/L,（9.35±2.60）μmol/L,48.57±15.64ng/L（P﹤0.001）.There was a positive correlation between Hcy and hsCRP,Hcy and ET（r = 0.731,0.532,P﹤0.01）.[Conclusion]The levels of hsCRP and Hcy and ET in the patients with coronary heart disease are significantly increased.Hcy,hsCRP and ET may play a part in the development and growth of coronary atherosclerosis.

关 键 词：冠状动脉疾病 超敏-C反应蛋白 同型半胱氨酸 内皮素 

分 类 号：R541.4[医药卫生—心血管疾病]