大气颗粒物暴露同社区中老年人群血清中C反应蛋白变化关系  

Ambient Particulate Pollutants and C Reactive Protein Variability in Elderly Residents in Beijing

作　　者：董少霞[1] 程义斌[1] 徐东群[1] 洪燕峰[1] 康家琦[1] 张广生[1] 王秦[1] 李东亮[2] 金银龙[1] 

机构地区：[1]中国疾病预防控制中心环境与健康相关产品安全所,北京100021 [2]北京市朝阳区疾病预防控制中心

出　　处：《环境与健康杂志》2011年第12期1035-1039,共5页Journal of Environment and Health

基　　金：国家空气污染与疾病监测点项目;美国NIH Fogarty项目(5D43TW007864-09)

摘　　要：目的探讨大气颗粒物暴露水平改变同机体C反应蛋白(CRP)水平之间的关系。方法于2008年在北京市朝阳区招募了236名社区中老年人,分别于北京奥运交通限行前(7月)和限行后(9月)开展两次现场调查,采集静脉血测定血清CRP水平,通过问卷获得人群的基本信息及健康特征;同时监测人群所在社区大气颗粒物(PM2.5、PM10)浓度,用于评价社区人群大气颗粒物暴露水平。结果 236名社区中老年人(≥45岁)的平均年龄为(60.77±7.99)岁,限行后血清CRP平均水平(中位数为3.10 mg/L)明显低于限行前(中位数为4.25 mg/L)(P<0.000 1)。社区大气颗粒物PM2.5平均水平由限行前的54μg/m3降低至限行后的33μg/m3,PM10则由142μg/m3降低至63μg/m3。经多元逐步回归分析,年龄与血清CRP变化量呈负相关关系;有心脑血管疾病史者CRP水平较高,且变化量较大;大气颗粒物浓度变化同CRP水平的改变呈正相关。结论北京奥运交通限行措施使社区大气颗粒物水平进一步降低,人群炎症反应明显好转,CRP水平降低;机体CRP水平的改变同心脑血管疾病史和颗粒物暴露浓度相关。Objective To know the effects of the particulate pollutants on C-reactive protein （CRP） level during the Beijing Olympic Games. Methods A total of 236 elderly residents of three communities in Chaoyang district, Beijing were recruited to join the project in 2008. Twice field surveys,in Jun. and Sep. including questionnaire, physical examination and blood sampling were conducted before and after the Olympics Games （before and after traffic restriction）, respectively. CRP was measured for the subjects in both surveys. Before each field study, ambient particulate pollutants （PM2.5 and PM10） were monitored for three consecutive days in the communities where the subjects hved to evaluate the exposure level of the subjects. Results The mean age of the subjects was （60.77 ±7.99） years. The median CRP level monitored in two surveys were significantly different with the lower level in second survey （before traffic restriction： 4.25 mg/L ; after traffic restriction： 3.10 mg/L, P〈0.000 1）. PM2.5 concentration reduced from 54 μg/m^3 at the first survey to 33 μg/m^3 monitored at the second survey and PM10 concentration reduced from 142 μg/m^3 to 63 μg/m^3. Through multi-factor line regression analysis, age was negatively related to CRP variety and history of cardiovascular disease was related to CRP variety too. CRP level was higher and its variety was larger for those who had ever got cardiovascular disease. Particulate matter exposure level was also positively related to CRP. The more exposure level decreased, the more CRP concentration changed. Conclusion Ambient particulate matter decreases after the traffic restriction and inflammation improves significantly with lower CRP concentration. Cardiovascular disease and PM exposure level are all related to CRP concentration.

关 键 词：空气污染 颗粒物 C反应蛋白 交通限行 北京奥运会 

分 类 号：R181.3[医药卫生—流行病学]