药品不良反应1393例报告分析  

Analysis of 1393 adverse drug reaction reports

作　　者：杨天燕[1] 李梅[1] 王劲[1] 黄晓青[1] 

机构地区：[1]广西医科大学第一附属医院药剂科,南宁530027

出　　处：《中国临床新医学》2011年第12期1135-1139,共5页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

摘　　要：目的了解药品不良反应(ADR)发生的特点及一般规律,为临床合理用药提供依据。方法采用回顾性研究方法,对2008-01～2011-06收集到的1 393例ADR报告进行统计分析。结果 1393例ADR报告中,共计1 666例次药品引起ADR,涉及品种211种,其中约5%涉及2种以上药物联用。其中抗微生物类药的ADR发生率最高(860例次,占51.62%),其次为营养支持及能量代谢药(150例,占9%);发生ADR主要的给药途径为静脉注射(1 211例,占86.93%);药物剂型中以注射剂为主(1 518例次,占91.12%);ADR累及器官或系统主要为皮肤及其附件(760例,占54.56%),其次为全身性和消化系统。ADR转归中,1 389例ADR治愈或好转,2例出现后遗症,死亡2例。结论 ADR的发生与诸多因素有关,临床需加强ADR的监测和报告,以促进临床安全合理用药。Objective To comprehend the characteristics and general rifles of adverse drug reaction（ADR） in our hospital, in order to provide suggestion for rational use of medicines in clinical practice. Methods A retro- spective analysis of 1393 ADR reports in our hospital from Jan. 2008 to Jun. 2011 were analyzed. Results Of 1393 ADR reports, with total 1 666 cases of drugs induced ADR 211 classes of drugs were involved, and drugs combination more than one class approximated 5%. The greatest proportion of ADR was caused by antimicrobial agents （860 cases, 51.62% ）, followed by agents for nutritional support and energy metabolism （ 150 cases, 9% ） ; Main route of administration was intravenous injection （1 211 reports, 86. 93% ） ; The doseage-form of medicine was injection primarily （1 518 cases, 91.12% ）; Organ or system involved in ADR mainly were skin and its appendants （760 reports,54. 56% ）, followed by systemic and digestive system. In outcome of ADR, 1389 patients were cured or improved, 2 patients suffered from sequelae, 2 patients died. Conclusion The occurrence of ADR is related to many factors. ADR monitoring and report should be strengthened in the clinic, in order to promote rational and safe use of medicines in the clinic.

关 键 词：药品不良反应 报告 分析 合理用药 

分 类 号：R969.3[医药卫生—药理学]