自动化分析仪检测NSTE-ACS患者血清BNP与sST2水平变化分析  

Determination of serum levels of BNP and sST2 with automatic biochemical analyzer in patients with NSTE-ACS

作　　者：高建华[1] 林凌云[2] 邹文蓉[3] 文洪林[2] 

机构地区：[1]首都医科大学附属北京世纪坛医院检验科,北京100038 [2]北京中医医院检验科,北京100010 [3]北京积水潭医院检验科,北京100035

出　　处：《中国医学装备》2011年第12期89-91,共3页China Medical Equipment

摘　　要：目的:探讨自动化分析仪检测非ST段抬高急性冠状动脉综合征(NSTE-ACS)患者血清B型钠尿肽(BNP)与血清可溶性ST2(sST2)水平的变化情况。方法:选择2008年4月至2011年4月在我院就诊的非ST段抬高心肌梗死(NSTEMI)患者139例,不稳定型心绞痛(UA)患者94例和正常体检的健康对照组30名作为研究对象,使用雅培AXSYM全自动发光分析仪进行血清BNP和sST2浓度的定量检测,分别采用微粒子捕捉酶促免疫发光分析技术(MEIA)和酶联免疫吸附试验(ELISA)。结果:健康对照组、UA组和NSTEMI组间的血清BNP水平分分别为16.9±9.7,92.7±68.3和296.7±111.5,(P<0.01),sST2水平分分别为0.65±0.27,0.83±0.22和1.35±0.53,(P<0.01)呈梯度增高,且各组间皆具有显著性差异(P<0.05)。相关分析显示,NSTE-ACS患者血清BNP水平与sST2水平呈显著正相关(r=0.722,P<0.001)。结论:血清BNP和sST2水平检测有助于对NSTE-ACS的诊断。Objective：To study the efficiency of automatic biochemical analyzer in determination of serum B-type natriuretic peptide （BNP） and soluble ST2 （sST2）in patients with acute coronary syndrome. Methods：From Apr.2008 to Apr.2011, 193 patients with non-Q wave myocardial infarction（NSTEMI）, 94 with unstable angina pectoris （UA） and 30 with complete medical check-up in our hospital were recruited in this study. The serum BNP and soluble ST2 were measured by MEIA and ELISA, respectively. Results：There were significant differences of serum BNP and sST2 in each groups of NSTEMI patients, UA patients and normal controls （P0.05）. One-way ANOVA trend analysis indicated that the mean serum BNP and sST2 increased significantly from normal controls to NSTEMI patients （P0.01）. The serum BNP had a significant correlation with sST2 in patients with acute coronary syndrome （r=0.722, P0.001）. Conclusion：The changes of serum BNP and sST2 contribute to diagnose acute coronary syndrome.

关 键 词：自动化 B型钠尿肽 sST2 急性冠脉综合征 

分 类 号：R541.4[医药卫生—心血管疾病]