卡维地洛联合坎地沙坦对心力衰竭患者血浆N末端B型利钠肽原浓度的影响  

Effects of Carvediol combined with Candesartan on the level of N-terminal pro-brain natriuretic peptide in patients with congestive heart failure

作　　者：张闯[1,2] 郭慧 唐发宽 唐雪正 张卫华[3] 单兆亮[1] 

机构地区：[1]军医进修学院,北京100853 [2]解放军第三○九医院心内科,北京100091 [3]河北省保定市易县医院急诊科,河北保定074200

出　　处：《中国医药导报》2011年第36期73-75,共3页China Medical Herald

摘　　要：目的:观察卡维地洛联合坎地沙坦对心力衰竭(CHF)患者血浆N末端B型利钠肽原(NT-proBNP)浓度的影响。方法:将175例CHF患者随机分为对照组(常规治疗)和治疗组(卡维地洛联合坎地沙坦治疗)。分别于用药前及用药3个月后测定血浆NT-proBNP浓度、左心室射血分数(LVEF)、左室短轴缩短率(FS)及心脏指数(CI)。结果:治疗组总有效率为87.5%,对照组总有效率为70.1%,治疗组较对照组明显提高(P<0.01),两组治疗后的LVEF、FS、CI、血浆NT-proBNP浓度明显改善(治疗组t=23.167、14.041、6.602、60.735,均P<0.01;对照组t=4.943、4.698、3.73、48.673,均P<0.05);治疗后治疗组LVEF、FS、CI较对照组改善显著(t=15.948、6.822、5.88,均P<0.01),血浆NT-proB-NP浓度明显降低(t=14.794,P<0.01)。结论:卡维地洛联合坎地沙坦可改善CHF患者心功能,降低血浆NT-proBNP浓度,对治疗心力衰竭安全有效。Objective：To investigate the effects of Carvediol combined with Candesartan on the level of N-terminal pro-brain natriuretic peptide（NT-proBNP） in patients with congestive heart failure.Methods：175 patients were randomly divided into control group（conventional treatment） and treatment group（Carvediol combined with Candesartan）.NT-proBNP levels,left ventricular ejection fraction（LVEF）,left ventricular fractional shortening（FS） and cardiac index（CI） were evaluated before therapy and after therapy for 3 months.Results：After therapy for 3 months,the effectiveness rate was 87.5% in treatment group and 70.1% in control group,the rate of treatment group was much higher than control group（P〈0.01）;the values of LVEF,FS,CI and NT-proBNP levels were improved after treatment in both groups（in treatment group,t=23.167,14.041,6.602,60.735,all P〈0.01;in control group,t=4.943,4.698,3.73,48.673,all P〈0.05）;compared with the control group,the values of LVEF,FS,CI were improved significantly（t=15.948,6.822,5.88,P〈0.01） and the value of NT-proBNP level was much lower（t=14.794,P〈0.01）.Conclusion：Carvediol combined with Candesartan may markedly decline NT-proBNP level for patients with CHF and improve patient＇s cardiac function.

关 键 词：卡维地洛 坎地沙坦 脑利钠肽 心力衰竭 心功能 

分 类 号：R541.61[医药卫生—心血管疾病]