老年慢性左心衰严重程度与循环EMP62E和Toll样受体水平变化的关系  

The relationship between various degrees of chronic left heartfailure and changes of circulating endothelial microparticles(EMP62E),TLR2 and TLR4 in the elderly

作　　者：陈颖[1] 李侠[1] 郭燕[1] 胡有东[1] 周华兰[1] 杨海晨[1] 李霞[1] 韩雪花[1] 

机构地区：[1]徐州医学院附属淮安医院老年病科,江苏淮安223002

出　　处：《实用临床医药杂志》2011年第24期10-12,共3页Journal of Clinical Medicine in Practice

基　　金：江苏省高校自然科学研究计划项目(KJD310234);江苏省淮安市科技局科技项目(HAS04020)

摘　　要：目的研究循环内皮细胞微颗粒(EMP62E)和Toll样受体2(TLR2)、Toll样受体4(TLR4)水平变化与老年慢性左心衰严重程度的相关性。方法根据NYHA心功能分级和左室射血分数(LVEF)将健康对照者和老年慢性左心衰患者分为对照组、Ⅰ、Ⅱ、Ⅲ和Ⅳ级组。采用流式细胞仪检测健康对照者和老年慢性左心衰患者EMP62E、TLR2和TLR4的表达。结果随着NYHA心功能分级的升高和LVEF的下降,EMP62E、TLR2和TLR4的表达水平明显上升。TLR2、TLR4和EMP62E水平变化趋势为:冠心病组>高血压组>对照组。结论 EMP62E、TLR2和TLR4的水平显著升高可能参与了老年慢性左心衰发生发展的机制。Objective To study the relationship between expression of circulating endothe- lial microparticles （EMP62E）, TLR2 and TLR4 and various degrees of chronic left heart failure in elderly patients. Methods According to New York Heart Association （NYHA）class and left ven- tricular ejection fraction （LVEF）, the healthy subjects and the patients were divided into five groups： control group, class I group, class Ⅱgroup, class Ⅲ group and class Ⅳ group. The ex- pression of circulating EMP62E, TLR2 and TLR4 of the patients and healthy subjects was mea- sured by flow cytometry. Results With the increase of NYHA class and decline of LVEF, EMP62E, TLR2 and TLR4 expression levels were significantly increased. TLR2, TLR4 and EMP62E level trends were as follows： coronary heart disease group 〉 hypertension group 〉 control group. Conclusion The upregulation of circulating EMP31, TLR2 and TLR4 may contribute to the development of chronic heart failure in the elderly.

关 键 词：老年人 慢性左心衰 内皮细胞微颗粒 TOLL样受体 

分 类 号：R514[医药卫生—内科学] R392.12[医药卫生—临床医学]