IgA肾病患者AGT M235T基因多态性分析  

Correlation of AGT M235T polymorphism with the susceptibility and clinicopathologic phenotypes of IgA nephropathy

作　　者：黄海东[1] 李新娟[1] 王立瑞[1] 蒋更如[1] 朱淳[1] 

机构地区：[1]上海交通大学医学院附属新华医院肾脏内科,上海200092

出　　处：《实用临床医药杂志》2011年第24期57-59,65,共4页Journal of Clinical Medicine in Practice

基　　金：中国高校医学期刊临床专项资金(11120031)

摘　　要：目的探讨血管紧张素原(AGT)M235T基因多态性与上海地区IgA肾病(IgAN)遗传易感性及临床病理表现的相关性。方法选取上海地区经肾穿刺病理活检证实为IgAN患者105例和健康对照者120例,采用聚合链式反应-限制性片段长度多态性技术(PCR-RFLP)检测AGT M235T基因多态性,并比较不同基因型患者临床病理表现之间的相关性。结果 105例IgAN肾病患者的AGT M235T基因多态性与正常对照相比,基因型分布频率差异无统计学意义;年龄、性别、血压、血清肌酐、24 h尿蛋白定量、初始的估算肾小球滤过率(eGFR)值等临床指标与AGT M235T基因型无相关性;病理资料显示AGT M235T各基因型病理表现无相关性。结论 AGT M235T基因多态性与IgAN患者无显著相关性。Objective To study the relationship between AGT M235T polymorphism with the susceptibility and clinicopathologic phenotypes of IgA nephropathy. Methods A total of 105 patients from Shanghai region with IgA nephropathy and 120 normal controls were enrolled in the study. RPC RFLP was applied to detect the gene polymorphism of AGT M235T. The genetic association of genotypes with the clinical and pathologic phenotypes was analyzed. Results Compared with controls, AGT genotype distributions were similar in IgAN patients. There were no differences between genotypes in age, sex, blood pressure, 24 h urine protein excretion, serum creatinine and estimated glomerular filtration rate. There were also no differences between genotypes in pathological lesions. Conclusion AGT M235T polymorphism does not significantly associate with IgA nephropathy.

关 键 词：IGA肾病 血管紧张素原 基因多态性 

分 类 号：Q75[生物学—分子生物学] R692[医药卫生—泌尿科学]