地佐辛与芬太尼患者自控静脉镇痛的比较  

Comparison of the analgesic effects of Dezocine or Fentanyl for intravenous patient-controlled analgesia

作　　者：王军[1] 王志萍[1] 黄东晓[1] 

机构地区：[1]江苏省无锡市人民医院麻醉科,江苏无锡214023

出　　处：《实用临床医药杂志》2011年第24期113-114,124,共3页Journal of Clinical Medicine in Practice

摘　　要：目的比较地佐辛与芬太尼自控静脉镇痛(PCIA)的镇痛效果和不良反应。方法将120例胆囊切除术患者随机均分为A、B 2组,每组60例。术后A组PCIA采用地佐辛1 mg/Kg、氟哌利多5 mg,B组PCIA采用芬太尼18μg/Kg、氟哌利多5 mg,分别于术后4、8、12、24 h采用视觉模拟评分法(VAS)评定镇痛效果,并记录不良反应情况。结果 2组患者术后镇痛效果无显著性差异;2组均未见血压心率的波动及呼吸抑制等严重并发症发生;A组镇静评分为Ⅰ~Ⅳ级的比例显著低于B组,其余不良反应发生率与B组均无统计学差异。结论地佐辛PCIA镇痛效果可靠,不失为一种比较好的PCIA方法。Objective To compare the analgesic effects and adverse reactions of Dezocine or Fentanyl for patient - controlled intravenous analgesia （PCIA）. Methods 120 patients undergoing cystic resection were randomly divided into 2 groups with 60 cases each. They received PCIA after operation. The PCIA solution contained Dezocine 1 mg/kg and Droperido 15 mg in 100 mL of normal saline （N. S. ） in group A or Fentanyl 18 ~g/t^g and Droperido 15 mg in 100 mL of N.S. in group B. VAS was used to measure pain intensity and their side effects were recorded at 4, 8, 12, 24 h after operation. Results There： was no significant difference in VAS score. There was no wave of blood pressure, heart rate and breath suppression in the two groups. The rate of calm score with Ⅰ～Ⅳ grades in group A was obviously lower than that in group B, and there was no significant difference in the rest adverse effects between the two groups. Conclusion The analgesic effect of Dezocine PCIA is a reliable and better PCIA method.

关 键 词：地佐辛 芬太尼 胆囊切除术 镇痛 

分 类 号：R971[医药卫生—药品]