正常高值血压者冷加压试验血压变化与血压变异的相关性  

Association between cold pressure test for blood pressure and blood pressure variability in prehypertensives

作　　者：路方红[1] 刘振东[1] 赵颖馨[1] 王舒健[1] 孙尚文[1] 胡小亮[1] 李俊[1] 

机构地区：[1]山东省医学科学院基础医学研究所,济南250062

出　　处：《中华高血压杂志》2011年第11期1039-1043,共5页Chinese Journal of Hypertension

基　　金：山东省科技发展计划项目(2011GSF11822);山东省自然科学基金项目(ZR2009CL029;ZR2011HQ053);山东省医学科学院项目(2009-16;2009-17;2010-13)

摘　　要：目的探讨正常高值血压者冷加压试验血压变化与24h血压变异相关性。方法将受试者261人按血压水平分为理想血压组、正常高值血压组和高血压组。所有受试者均进行冷加压试验、24h动态血压监测及血液生化指标检测。结果正常高值血压组三酰甘油、空腹血糖高于理想血压组(P<0.05);正常高值血压者冷加压后0及60s收缩压增加幅度分别为(14.0±6.5)及(9.3±5.0)mmHg,冷加压试验阳性率为25.6%,低于高血压组,但明显高于理想血压组(P<0.05);正常高值血压组24h、白天及夜间收缩压、舒张压变异均明显高于理想血压组(P<0.05);正常高值血压组0s收缩压增加幅度与夜间收缩压变异、24h收缩压变异呈正相关(r=0.625和r=0.512,均P<0.01);60s收缩压增加幅度与夜间收缩压、舒张压变异呈正相关(r=0.617和r=0.533,均P<0.01)。结论正常高值血压者交感神经系统活性增强,冷加压后血压增加幅度上升,血压变异性增加,冷加压后血压增幅与血压变异相关。Objective To explore the correlation between blood pressure changes of cold pressure test and 24 hours blood pressure variability in prehypertensives. Methods According to blood pressure level, 261 participants were divided into three groups, namely, normotensive group, prehypertensive group and hypertensive group. Cold pressure test, 24 hours ambulatory blood pressure monitoring and blood test were conducted in all participants. Results Triglycerides and fasting plasma glucose in prehypertensive group were higher than those in normotensive group （P〈0.05）. The increased amplitude of systolic blood pressure {SBP） at baseline and sixty seconds after cold pressure test were （14.0＋6.5） and （9.3＋5.0）mm Hg, respectively, and the rate of positive cold pressure test was 25.6% in prebypertensive group, lower than those in hypertensive group, higher than those in normotensive group （P〈0.05）. The systolic and diastolic blood pressure （DBP} variability of 24 hours, day time and night time in prehypertensive group were higher than those in normotensive group （P〈0. 05）. The increased amplitude of SBP at baseline after cold pressure test positively correlated with night time and 24 hours SBP variability. The increased amplitude of SBP at sixtieth second after cold pressure test significantly correlated with night time systolic and diastolic blood pressure variability. Conclusion The sympathetic nervous system activity has been enhanced in prehy- pertensives. The amplitude of blood pressure and blood pressure variability in prehypertensives after cold pressure test are increased. The increased amplitude of blood pressure associates with blood pressure variability in prehyper- tensives after cold pressure test.

关 键 词：正常高值血压 交感神经活性 冷加压试验 血压变异 

分 类 号：R544.1[医药卫生—心血管疾病]