慢性肾脏病伴高血压患者的动态血压与心率变异性分析  

Analysis of Ambulatory Blood Pressure and Heart Rate Variability in Patients with Chronic Kidney Disease with Hypertension

作　　者：张红珊[1] 李波[1] 纳志英[1] 王月[1] 李奕林[1] 尹琳[1] 

机构地区：[1]昆明医学院第二附属医院心功能科,云南昆明650101

出　　处：《昆明医学院学报》2011年第11期108-111,共4页Journal of Kunming Medical College

摘　　要：目的探讨慢性肾脏病伴高血压患者(HCKD)动态血压及心率变异性(HRV)的变化特点.方法随机选择56例HCKD患者,44例原发性高血压(EH)患者和43例正常对照组,同步监测动态血压和动态心电图,并对比分析其动态血压参数及HRV变化的特点.结果与EH组比较,HCKD组的动态血压参数平均24 hS-BP、平均24 hDBP、平均NSBP、平均NDBP高于EH组(P<0.05),HCKD组发生非杓型血压比例(89.28%)高于EH组(70.46%)(P<0.05),而HRV时域法指标:SDNN、SDANN、rMSSD、PNN50均低于EH组,差异有统计学意义(P<0.05).结论HCKD患者平均24 h及夜间血压增高、血压昼夜节律异常、HRV明显降低.Objective To investigate the characteristics of changes of ambulatory blood pressure and heart rate variability（HRV）in patients with chronic kidney disease with hypertension（HCKD）.Methods 56 patients with HCKD,44 patients with essential hypertension（EH）and 43 normal subjects were selected randomly,and their ambulatory blood pressure and dynamic electrocardiogram were simultaneously monitored to compare and analyze their ambulatory blood pressure parameter and the varied characteristics of HRV.Results Compared with EH group,the ambulatory blood pressure parameters including mean24DBP,meanNSBP and meanNDBP were higher significantly in HCKD group（P0.05）,and the ratio of non-dipper hypertension（89.28%）in HCKD group was higher than EH group（P0.05）.However,the HRV time domain indexes including SDNN,SDANN,rMSSD and PNN50 were significantly lower than those in EH group（P0.05）.Conclusion The average blood pressure of the HCKD patients in 24 hours and at night increase with abnormal circadian rhythm of blood pressure and significant decrease of HRV.

关 键 词：慢性肾脏病伴高血压 动态血压 昼夜节律 心率变异性 

分 类 号：R544.1[医药卫生—心血管疾病] R540.4[医药卫生—内科学]