吡喹酮直肠给药治疗小鼠血吸虫病实验研究  

Experiment of praziquantel rectal administration in treatment of schistosomiasis in mice

作　　者：杨艺[1,2] 王建民 江艳[2] 李小红[2] 刘毅[2] 朱传刚[2] 石耀军[2] 

机构地区：[1]沈阳农业大学畜牧兽医学院,沈阳110866 [2]中国农业科学院上海兽医研究所、农业部动物寄生虫学重点开放实验室

出　　处：《中国血吸虫病防治杂志》2011年第6期674-676,686,共4页Chinese Journal of Schistosomiasis Control

基　　金：国家公益性行业(农业)科研专项基金(200903036)

摘　　要：目的观察吡喹酮直肠给药对小鼠日本血吸虫病的治疗效果。方法各实验组每只小鼠分别腹部贴片感染日本血吸虫尾蚴40±2条。感染后第42天以吡喹酮直肠给药,按给药不同剂量设为3组,每组每只小鼠按100、200、400mg/kg一次给药,同时设不给药对照组。给药1周后进行剖杀,计算减虫率、减肝卵率以及减配对率。结果 200mg/kg组减虫率为57.63%,减配对率为76.60%;400mg/kg组减虫率为49.15%,减配对率为51.06%,减虫率、减配对率效果优于100mg/kg组。结论吡喹酮直肠给药方式效果较好,可为防治家畜血吸虫病提供新的选择。Objective To evaluate the efficiency of rectal administration of praziquantel in the treatment of schistosomiasis in mice. Methods Forty mice were divided into 4 groups. Each mouse was infected with Schistosoma japonicum cercariae 40±2. Forty-two days after the infection, the mouse was rectally administered with different doses of praziquantel. In the first, second and third group, each mouse was given 100, 200 mg/kg, and 400 mg/kg single dose of praziquantel, and the fourth group was a blank control group. One week after the administration, all the mice were sacrificed and the worm reduction rate, reduction rate of liver eggs, and matching reduction rate were calculated. Results The worm reduction rate and matching reduction rate were 57.63% and 76.60% respectively in the 200 mg/kg group, and 49.15% and 51.06% respectively in the 400 mg/kg group, which were better than those in the 100mg/kg group. Conclusion Rectal administration of praziquantel has good efficiency in the treatment of schistosomiasis in mice; therefore, it provides a new option for the prevention and control of animal schistosomiasis.

关 键 词：日本血吸虫病 吡喹酮 直肠给药 小鼠 

分 类 号：R532.21[医药卫生—内科学]