烫伤严重度及延迟复苏对小肠推进功能的影响  

The effect of severity of burns and delayed resuscitation on intestinal propulsive movement in rats

作　　者：王少根[1] 陈侠英[1] 汪昌荣[1] 王永杰[1] 

机构地区：[1]安徽医科大学附属医院烧伤科,安徽合肥230022

出　　处：《中国危重病急救医学》2000年第2期83-84,共2页Chinese Critical Care Medicine

基　　金：安徽省教委科研基金!(4291# )

摘　　要：目的：探讨烫伤严重程度及延迟复苏对小肠推进功能的影响，为烫伤后肠动力功能的维持提供理论指导和实践手段。方法：采用１０％ 、２０％ 和３０％ 小鼠背部Ⅲ度烫伤模型。伤后１ 小时按Ｐａｒｋｌａｎｄ 公式行腹腔输液复苏；伤后１２ 小时碳素墨汁灌胃，２５ 分钟后处死小鼠，计算小肠推进率。延迟复苏组则于伤后６ 小时复苏。结果：伤后１２ 小时见３种程度烫伤小鼠小肠推进率都下降，且随烫伤面积的增大而下降增多；延迟复苏组小肠推进率下降最明显。结论：严重烫伤后小肠推进功能受损，面积越大受损越重，延迟复苏对小肠推进功能影响最大。烫伤后小肠推进功能维护与改善对多器官衰竭的防治有极重要意义。Objective:To investigate the effect of severity of burns and delayed resuscitation on intestinal propulsive movement in a bid to improve gastrointestinal motility and prevent multiple organ failure.Methods:Rats were subjected to 10%,20%,and 30% total body surface area fullthickness thermal injury,and they were given resuscitation according to the Parkland formula an hour later.The animals were gavaged with blackink at 12 hours after injury,and were sacrificed 25 minutes later to observe intestinal propulsive rate.Results:In rats with different degrees of thermal injury severity,the intestinal propulsive rate was uniformly decreased.The intestinal propulsive rate was decreased along with the increase in extent of thermal injury,and it reached a very low level in animals with delayed resuscitation.Conclusions:Intestinal propulsive movement is severely impaired after severe burns,and improvement of intestinal propulsive movement may have significance for prevention of multiple organ dysfunction syndrome resulted from major burns.

关 键 词：烫伤 小肠推进率 延迟复苏 治疗 

分 类 号：R644[医药卫生—外科学]