低血容量性休克大鼠全身氧动力学的变化研究  

Characteristics of oxygen kinetics in rats during hemorrhagic shock

作　　者：单红卫[1] 陈学云[1] 杨兴易[1] 景炳文[1] 

机构地区：[1]第二军医大学长征医院急救科,上海200003

出　　处：《中国危重病急救医学》2000年第2期85-86,共2页Chinese Critical Care Medicine

摘　　要：目的：研究低血容量性休克时全身氧动力学的变化特点。方法：按４ ｍ ｌ／ｋｇ、每隔０．５ 小时分次从静脉放血，观察大鼠休克过程中全身氧供给（ＤＯ２ ）、氧消耗（ＶＯ２ ）和氧摄取率（ＥｘｔＯ２ ）的变化。结果：失血后１．５ 小时血红蛋白浓度开始显著降低（Ｐ均＜ ０．０５），心率明显加快（Ｐ均＜ ０．０５）；失血２．０ 小时平均动脉压明显下降（Ｐ均＜ ０．０１），此时ＤＯ２ 亦开始进行性下降，由于ＥｘｔＯ２ 出现代偿升高，ＶＯ２ 维持相对不变；失血３．０ 小时时，ＶＯ２ 随ＤＯ２ 一并降低，呈氧供依赖关系，并伴血乳酸浓度升高。结论：低血容量性休克时出现氧供依赖关系，该关系反映了全身组织缺氧的存在。Objective:To investigate the characteristics of oxygen kinetics during hemorrhagic shock.Methods:A rat model of hemorrhage was established by withdrawing venous blood in 4 ml/kg every 0 5 hour interval.Systemic oxygen delivery (O 2),oxygen consumption (O 2) and oxygen extraction (ExtO 2) were measured in rats during hemorrhagic shock.Results:Blood hemoglobin concentrations decreased (all P <0 05) and heart rates significantly increased (all P <0 05) at 1 5 hours of hemorrhage.2 hours after hemorrhage,mean arterial pressure significantly lowered (all P <0 01),while O 2 progressively decreased,O 2 remained relative stable which was attributed to an increase in ExtO 2 compensatively.After 3 0 hours of hemorrhage,O 2 significantly decreased ( P <0 01) associated with reduction in O 2,manifesting dependence of O 2 on O 2,and it was associated with elevation of blood lactate concentrations.Conclusions:Dependency of O 2 on O 2 exists in hemorrhagic shock,and such relation is indicative of body tissue hypoxia.

关 键 词：休克 低血容量性 大鼠 氧消耗 氧供给 

分 类 号：R441.9[医药卫生—诊断学]