类风湿因子与抗环瓜氨酸肽抗体在诊断类风湿关节炎中的应用  

Application of Rheumatoid Factor and Anti-cyclic Citrullinated Peptide Antibody in Diagnosis of Rheumatoid Arthritis

作　　者：刘金禄[1] 何晓峰[1] 王蕾[1] 李采青[1] 赵海春[1] 卢成[1] 

机构地区：[1]河北北方学院附属第一医院微生物科,河北张家口075000

出　　处：《河北北方学院学报（自然科学版）》2011年第6期79-80,共2页Journal of Hebei North University:Natural Science Edition

摘　　要：目的通过对类风湿关节炎(RA)患者及非RA患者血清中的类风湿因子(RF)与抗环瓜氨酸肽抗体(抗-CCP抗体)水平测定,探讨抗-CCP抗体在RA的诊断价值.方法用酶联免疫吸附方法对49例RA、61例非RA患者测定血清抗CCP抗体及RF,并对检测结果进行比较.结果 49例RA患者中抗-CCP抗体阳性23例,61例非RA患者抗-CCP抗体阳性2例.抗-CCP抗体的特异性比RF高,但敏感性比RF低.结论抗-CCP抗体对RA具有高度的特异性,抗-CCP抗体对RA患者的诊断具有非常重要的价值.Objective To evaluate the significance of anti-cyclic citrullinated peptide antibody （anti CCP） in diagnosis of rheumatoid arthritis （RA） by comparing rheumatoid factor （RF） with anti-cyclic citrullinated peptide antibody （anti CCP）. Methods ELISA was used to detect anti-CCP in 49 RA patients and 61 patients without RA, and the results were analyzed. Results Positive anti-CCP was found in 23 patients with RF and 2 patients without RA, the specificity of anti CCP was higher than that of RF, while its sensibility was lower than that of RF. Conclusion Anti CCP had high degree of specificity to RA, and anti CCP was very important in diagnosis of RA patients.

关 键 词：类风湿关节炎 类风湿因子 抗环瓜氨酸肽抗体 酶联免疫吸附测定 

分 类 号：R446[医药卫生—诊断学]