母牛分枝杆菌辅助治疗耐多药肺结核的Meta分析  

Meta-analysis on adjuvant effect of mycobacterium vaccae vaccine in the treatment of multi-drug resistant tuberculosis

作　　者：吴珂[1] 李国栋[1] 赵冠人[1] 冯端浩[1] 

机构地区：[1]解放军309医院药剂科,北京100091

出　　处：《中国药物应用与监测》2011年第6期341-345,共5页Chinese Journal of Drug Application and Monitoring

摘　　要：目的:评价母牛分枝杆菌菌苗辅助治疗耐多药肺结核的疗效。方法:搜集公开发表的有关母牛分枝杆菌治疗耐多药肺结核的随机对照临床试验,按照Meta分析的方法,运用Rev Man 4.2.10软件对符合条件的所有结果进行分析。结果:纳入文献10篇,总样本量3239例,辅用母牛分枝杆菌治疗组1644例,其中,痰菌转阴467例,病灶吸收433例,空洞闭合367例;未辅用母牛分枝杆菌治疗组1595例,其中,痰菌转阴332例,病灶吸收279例,空洞闭合229例。三项疗效指标合并OR值分别为3.61,3.12,3.19(P<0.01),表明疗效差异具有显著的统计学意义。结论:母牛分枝杆菌能增强耐多药肺结核化疗的效果,可用于辅助治疗耐多药肺结核。Objective： To evaluate the adjuvant effect of mycobacterium vaccae vaccine in the treatment of multi-drug resistant tuberculosis.Methods： We collected the randomized controlled clinical trials published comparing the effect of the mycobacterium vaccae immunotherapy group and the control group in the treatment of multi-drug resistant tuberculosis.Data were analyzed by using Rev Man 4.2.10 software.Results： There were ten trials including 3239 cases in the analysis.The mycobacterium vaccae immunotherapy group included 1644 cases,of which there were 467 cases of sputum negative,433 cases of lesion absorption,367 cases of cavity closure;the control group not assisted with vaccae treatment included 1595 cases,of which there were 332 cases of sputum negative,279 cases of lesion absorption,229 cases of cavity closure.OR values of three indices were 3.61,3.12,3.19（P 0.01） respectively.These differences were statistically signifi cant.Conclusion： Mycobacterium vaccae vaccine can enhance the effect of chemotherapy on the multi-drug resistant tuberculosis as adjuvant treatment.

关 键 词：母牛分枝杆菌 肺结核 耐多药 META分析 

分 类 号：R521[医药卫生—内科学]