药物相互作用致华法林抗凝作用增强引起出血的病例分析  

Analysis of bleeding induced by increasing the effect of anticoagulation due to drug interaction with warfarin

作　　者：郑策[1,2] 李锦[1,2] 毛璐[1,2] 甄健存[1,2] 

机构地区：[1]北京积水潭医院 [2]北京大学第四临床医学院药剂科,北京100035

出　　处：《中国药物应用与监测》2011年第6期356-358,共3页Chinese Journal of Drug Application and Monitoring

摘　　要：1例82岁女性房颤患者,服用华法林治疗2年余,INR控制在1.5～2.5,因肺部感染,合用氟康唑及头孢哌酮/舒巴坦钠等药物,用药后第4天,INR升至12.28,咯血。分析出血原因,建议立即停用华法林、输注冰冻血浆并给予维生素K1注射液等,2 d后INR降至1.3,出血停止。One 82-year-old female patient with atrial fibrillation,had taken warfarin for more than 2 years,and her international normalized ratio（INR） maintained in the range of 1.5 – 2.5.Due to pulmonary infection,the patient received ？ uconazole and cefoperazone/sulbactam sodium.Four days later,she developed hemoptysis and her INR raised to 12.28.Clinical pharmacists participated in the analysis of causes of bleeding and gave a series of recommendations,including withdrawing warfarin immediately,infusion of plasma and vitamin K1 and key points of rational use of vitamin K1 injection.After 2 days,her INR decreased to 1.3,and no further bleeding occurred.

关 键 词：华法林 出血 药物相互作用 临床药师 

分 类 号：R96[医药卫生—药理学]