N-(4-羧基苯基)-苯并异硒唑酮的合成工艺研究  

Research on an improved process for synthesis of N-(4-carboxyphenyl)-benzisoselenazolone

作　　者：李迎辉[1] 吴疆[1] 陈宝泉[1] 曹东华[1] 贺双艳[1] 罗振华[1] 

机构地区：[1]天津理工大学化学化工学院,天津300384

出　　处：《天津理工大学学报》2011年第5期64-67,共4页Journal of Tianjin University of Technology

基　　金：国家自然科学基金(20971097);教育部大学生创新性实验计划项目(2010)

摘　　要：以硒、硼氢化钾、对氨基苯甲酸等为原料,通过还原、缩合等反应合成了N-(4-羧基苯基)-苯并异硒唑酮,实验考查了还原剂、溶剂及反应时间对收率的影响,结果表明:还原剂为硼氢化钾,反应溶剂为乙醚-水,反应时间3 h,为较佳反应条件,总收率可达46.6%,目标物的结构经过IR、1H-NMR及ESI-MS等方法确证.N-（4-carboxyphenyl）- benzisoselenazolone was synthesized from selenium,potassium borohydride and 4-amino- benzoic acid by reducing and condensation. The effects of reducing agent, solvent and reaction time were discussed. The results indicate that the optimum condititions were ： potassium borohydride was used as the reducing agent, ether-water was used as the solvent and the reaction time was 3 h. The total yield was 46.6%. The target compound was indentified by IR, ^1H- NMR and ESI-MS.

关 键 词：硒 依布硒啉 N-(4-羧基苯基)-苯并异硒唑酮 合成 

分 类 号：TQ252[化学工程—有机化工]