急性重复高原缺氧对机体氧自由基代谢的影响  

The effect of acute repeated hypoxia to oxygen free radical metabolism of organism

作　　者：张西洲[1] 何富文[1] 陈占诗[1] 崔建华[1] 王伟[1] 马勇[1] 李朝斌[1] 张素萍[1] 

机构地区：[1]解放军第18医院

出　　处：《西藏医药》2000年第1期1-2,共2页Tibetan Medicine

摘　　要：目的：探讨急性重复高原缺氧对机体氧自由基代谢的影响。方法：对担负军事运输的某汽车部队随机挑选16名驾驶员，在开运前10天（海拔1400m）、完成4次高原（海拔1400-5400m）运输任务中途（海拔3700m）及运输任务结束（完成8次高原运输任务）后1个月（海拔1400m），分别进行3次血中抗氧化酶、抗氧化物和脂质过氧化物的检测。结果：运输前轻运输中途血红蛋白（Hb）、脂质过氧化物（LPO）、丙二醛（MDA）低，相差非常显著（P＜0．01）；红细胞超氧化物歧化酶（RBC—SOD）和VitE高，相差显著（P＜0．05）；运输前较运输后RBC－SOD和VitE高，LPO和MDA低，均相差非常显著（P＜0．01）。运输中途较运输结束Hb和RBC－SOD增高，相差非常显著和相差显著（P＜0．01和P＜0．05）。结论：低氧应激状态下和重复应激作用停止后的一定时间内，体内脂类过氧化活动显著增强，且持续时间较长。To explore the effects of acute re-peated hypoxia to oxygen free radical metabolism of organism. Method: To select 16 members of mil-itary drivers at random from a motor transport troops. The blood antioxidase, antioxide, lipid per-oxide(LPO) of them were detected for 3 times re-spectively: on the 10th day before transport task (1400m above sea level); at the midway(3700m above sea level ) when they had accomplished 4 rounds of transport task on high altitudes(1400 -5400m above sea level) and one month after they had accomplished 8 rounds of transport task on high altitudes(1400m theve sea level). Results: Before the transport task, Hb, LPO,MDA were decreased with highly significant difference(P<0.01), RBC - SOD, Vit. E were in-creased with significant difference(P <0. 05 ) than those at the midway; before the transport task,RBC - SOD, Vit. E were increased and LPO,MDA were decreased all with highly significant difference than those after transport; at the mid-way, Hb, RBC - SOD were increased with highly significant difference and significant difference(P<0. 01 and P <0. 05) than those after transport.Conclusion: In certain time of such hypoxia stress condition and after repeated hypoxia stress action stopped, intracorporal lipid peroxide activity was increased obviously with a rather long sustained time.

关 键 词：高原 急性重复缺氧 自由基反应 

分 类 号：R594.3[医药卫生—内科学]