高危型HPV检测联合细胞学检查在宫颈病变中的意义  

Significance of high-risk HPV test combined with cytological examination in cervical lesions

作　　者：宋萌颖[1] 陈东梅[2] 

机构地区：[1]山东省平度市人民医院妇科,266700 [2]淄博市临淄区人民医院妇科

出　　处：《中国妇幼保健》2012年第1期133-134,共2页Maternal and Child Health Care of China

摘　　要：目的:探讨高危型HPV检测联合细胞学检查在宫颈病变中的意义,为预防宫颈癌的发生及早期诊断与治疗提供进一步的指导依据。方法:该院2008年1月～2011年1月门诊自愿接受宫颈癌筛查的妇女2 697例,分别进行HR-HPV-DNA、TCT、HR-HPV-DNA+TCT检查,阳性病例均进行阴道镜活检。结果:2 697例进行筛查的妇女中标本发现异常涂片266例,占9.86%,其中意义不明的不典型鳞状细胞(ASCUS)170例,占6.30%,低度鳞状上皮内病变(LSIL)74例,占2.74%,高度鳞状上皮内病变(HSIL)72例,占2.67%,鳞状细胞癌(SCC)8例,占0.30%。266例TCT检测细胞学异常(ASCUS及以上)标本中高危型HPV阳性162例,HPV感染率60.90%。不同类型标本高危型HPV感染情况结果显示:ASCUS、LSIL、HSIL各组间的HPV感染率有统计学差异(P<0.01)。结论:将高危型HPV检测与TCT检测技术相结合应用于早期宫颈癌及癌前病变筛查中,提高了筛查宫颈病变的准确性。Objective： To explore the significance of high - risk HPV test combined with cytological examination in cervical lesions, provide further guidance and reference for prevention of occurrence, early diagnosis, and treatment of cervical cancer. Methods： A total of 2 697 women who received cervical screening voluntarily in outpatient department of the hospital from January 2008 to January 2011 were selected, then they underwent HR- HPV -DNA detection, TCT, and HR -HPV -DNA detection combined with TCT, the positive cases received biopsy under colposcope. Results： Among 2 697 cases, 266 cases were found with abnormal smears, accounting for 9. 86%, 170 cases were found with atypical squamous cells of undetermined significance （ASCUS）, accounting for 6. 30%, 74 cases were found with low - grade squamous intraepithelial lesions （ LSIL）, accounting for 2. 74%, 72 cases were found with high - grade squamous intraepithelial lesions （ HSIL）, accounting for 2. 67%, 8 cases were found with squamous cell carcinoma （ SCC）, accounting for 0. 30%. Among 266 cases with abnormal cytological smears （ASCUS and above）, 162 cases were found with positive high -risk HPV, the infection rate of HPV was 60. 90%. The conditions of different types of high - risk HPV infection specimens showed that there was significant difference in HPV infection rate among ASCUS group, LSIL group, and HSIL group （P 〈 0. 01 ） . Conclusion： High - risk HPV test combined with TCT used in screening of early cervical cancer and precancerous lesion of cervix improves the accuracy of screening for cervical lesions.

关 键 词：高危型HPV检测 细胞学检查 宫颈病变 

分 类 号：R446[医药卫生—诊断学] R711.74[医药卫生—临床医学]