邻二氮菲分光光度法测定盐酸氯丙嗪  

Spectrophotometric determination of chlorpromazine hydrochloride by 1,10-phenanthroline

作　　者：张一敏[1] 刘珂珂[1] 叶存玲[1] 王治科[1] 

机构地区：[1]河南师范大学化学与环境科学学院河南省环境污染控制重点实验室,新乡453007

出　　处：《分析试验室》2012年第1期39-41,共3页Chinese Journal of Analysis Laboratory

基　　金：国家自然科学基金项目(20977025)资助

摘　　要：在HAc-NaAc缓冲介质中,盐酸氯丙嗪(CPZ)能定量使Fe(Ⅲ)还原为Fe(Ⅱ),还原生成的Fe(Ⅱ)与邻二氮菲反应生成稳定的红色络合物,并且在一定范围内,CPZ的浓度和生成的红色络合物的吸光度呈良好的线性关系。据此,提出邻二氮菲-Fe(Ⅲ)体系测定盐酸氯丙嗪的新方法。在优化的实验条件下,盐酸氯丙嗪的质量浓度在0.040～15.00 mg/L范围内与吸光度呈现良好的线性关系,线性相关系数R=0.9995,摩尔吸光系数ε=2.8×104 L.mol-1.cm-1,检出限为0.020 mg/L。11次重复测定的相对标准偏差小于2.9%。该方法用于药物中盐酸氯丙嗪的测定,结果满意。A new spectrophotometric method for the determination of chlorpromazine hydrochloride in pharmaceuticals was proposed.The developed method was based on the redox reaction of chlorpromazine hydrochloride and Fe（Ⅲ） in the HAc-NaAc buffer solutions.The reaction product Fe（Ⅱ） can form a red colored product with 1,10-phenanthroline.Under the optimum conditions,the absorbance was proportional to the concentration of chlorpromazine hydrochloride in the range of 0.040～15.00 mg/L and the detection limit was 0.02 mg/L.The molar absorptivity was 2.8×104 L·mol-1·cm-1.The relative standard deviation of 11 replicate measurements was less than 2.9%.The proposed method has been applied to the determination of chlorpromazine hydrochloride in pharmaceuticals.

关 键 词：盐酸氯丙嗪 Fe(Ⅲ) 邻二氮菲 分光光度法 

分 类 号：O657.3[理学—分析化学]