肠道微生物作用的代谢组学研究及对中药作用机制研究的启示  

Metabonomics Investigation of Gut Microbiota on Host and Proposition on Mechanism of Action of Traditional Chinese Medicine

作　　者：尤蓉[1,2] 庞启华[1] 徐振波[2] 李琳[2] 

机构地区：[1]华南师范大学生命科学学院,广州510631 [2]华南理工大学轻工与食品学院,广州510640

出　　处：《天然产物研究与开发》2011年第B12期229-233,共5页Natural Product Research and Development

摘　　要：代谢组学是一门新兴学科和技术，广泛用于毒性、药物等作用机制的研究。通过代谢组学研究发现肠道微生物组影响机体代谢，进而影响机体对食品和药物的吸收利用。肠道微生物组对机体复杂的影响说明代谢组学方法将成为一种新型手段去研究中药经由肠道微生物组介导的中药多层次，多靶点的作用机制。Metabonomics is a new discipline and technology which has been widely applied to study the toxicology and n chanisms of the action of drugs. Metabonomics study indicated that gut micrabiota influenced the host metabolism and the availability and metabolism of drugs. The signicant involvement of the gut microbiota in host suggests that metabonomic will be a novel approach to evaluate the gut microbiota-mediated,multifactorial and multi-targeted mechanisms of traditional Chinese medicines.

关 键 词：代谢组学 肠道微生物组 中药 

分 类 号：Q591[生物学—生物化学] R28[医药卫生—中药学]