IL-17、IL-10在急性期和亚急性期川崎病患儿血清中浓度变化及意义  

Study on changes of IL-17,IL-10 in the serum of patients with KD in the acute and subacute phase

作　　者：段炤[1] 邹峥[1] 

机构地区：[1]江西省儿童医院风湿免疫科,南昌330006

出　　处：《江西医药》2011年第11期981-985,共5页Jiangxi Medical Journal

摘　　要：目的探讨急性期和亚急性期川崎病(kawasaki disease,KD)患儿血清IL-17及IL-10水平的变化,并进一步分析其临床意义。方法采用ELISA方法检测31例急性期及亚急性期KD患儿血清IL-17及IL-10的水平,并与同期22例健康儿童对照。结果急性期、亚急性期KD患儿组血清IL-17及IL-10水平均高于正常对照组(P<0.01);急性期KD患儿组血清IL-17及IL-10水平均高于亚急性期KD患儿组(P<0.01);急性期KD患儿血清IL-17水平与血清IL-10水平呈正相关。(r=0.630,P<0.05)。亚急性期KD患儿血清IL-17水平与血清IL-10水平呈负相关。(r=-0.810,P<0.05)。结论急性期KD患儿血清IL-17水平和IL-10水平均明显增高,亚急性期KD患儿血清IL-17水平显著下降,而亚急性期血清IL-10水平虽较急性期下降,但仍维持较高水平。IL-17是一种强的促炎细胞因子,而IL-10是一种抑炎细胞因子,二者血清水平的变化提示它们分别在KD发生和发展的不同阶段发挥着各自重要作用。在临床上可以通过检测血清IL-17和IL-10的水平为KD的诊断和治疗提供依据。Objective To investigate changes of the acute and subacute phase of Kawasaki disease （KD） serum levels of IL-17 and IL-10,and to analyze its clinical significance.Methods Using ELISA,31 patients with acute and subacute KD serum IL-17 and IL-10 levels and 22 cases detected over the same period age,gender no difference in the healthy children as controls.Results Children with acute,subacute KD serum IL-17 and IL-10 levels were higher than that of the control group （P〈0.01）;acute phase of KD patients IL-17 and IL-10 serum levels higher than the subacute KD serum levels of IL-17 and IL-10 （P〈0.01）; IL-17 and IL-10 of acute KD had positive correlation. （r=-0.630 ,P〈0.05）IL-17 and IL-10 of subacute KD had negative correlation. （r=-0.810,P〈0.05）. Conclusion The acute KD serum levels of IL-17 and IL-10 levels were increased, subacute KD serum levels of IL-17 and IL-10 levels decreased compared with the acute phase, and still higher than the normal control group, subacute period the decrease in IL- 10 than IL-17 is relatively small. IL-17 a potent pro-inflammatory cytokines, which IL-10 is an anti- inflammatory cytokine, suggesting that they were in the KD occurrence and development of play their important role at different stages. The level of IL-17 and IL-10 can be detected in clinical ,to understand some mechanisms of KD and disease pathogenesis, diagnosis and treatment for the KD to provide new clues and theoretical basis.

关 键 词：川崎病 急性期 亚急性期 白介素17 白介素10 

分 类 号：R725.4[医药卫生—儿科]