解脲支原体的致病性与Toll样受体  

Pathogenicity of Ureaplasma Urealyticum and Toll-like Receptors

作　　者：旷思思[1] 张洪文[1] 吴献青[1] 

机构地区：[1]中南大学湘雅二医院妇产科,长沙410011

出　　处：《国际妇产科学杂志》2011年第6期500-504,共5页Journal of International Obstetrics and Gynecology

摘　　要：解脲支原体(UU)是泌尿生殖道常见的、重要的条件致病菌,与泌尿生殖的多种炎性疾病有关。近年研究表明,UU感染与人乳头瘤病毒(HPV)感染及宫颈上皮内病变亦相关,然而UU感染的确切发病机制尚不清楚。UU细胞膜中含有丰富的脂蛋白,称脂质相关膜蛋白(lipid-associated membrane protein,LAMPs),可能是UU中的重要病原相关模式分子,LAMPs可与宿主细胞上特定的Toll样受体(TLRs)结合,激活信号传导通路,启动多种与炎症反应相关的基因转录,导致炎症介质的释放,引起机体炎性反应,这可能是UU重要致病机制,也是近年研究热点。综述UU感染与HPV感染相关性,以及UU的LAMPs及其与TLRs关系的最新研究。Ureaplasma species（Ureaplasma parvum and Ureaplasma urealyticum） are commonly found in the lower urogenital tract of healthy human as a kind of important opportunistic Bacteria.It is proved Ureaplasma spp.is associated with many acute and chronic infections of the urogenital tract.Recent studies show that ureaplasma infection may be involved in HPV infection and cytological abnormalities of cervix,but the roles of Ureaplasma plays in the pathogenesis of HPV-positive and abnormal cytology of cervix are still unclear.The plasma membrane of Ureaplasma species contains a lot of lipoprotein,called lipid-associated membrane protein（LAMPs） ,which may be an important Pathogen-associated molecular pattern.The LAMPs of Ureaplasma species can bind to specific TLRs of host cells,activating signaling transduction pathways,starting gene transcription and translation of proinflammatory cytokines,and then releasing a variety of pro-inflammatory factors,triggering inflammatory responses of the host.This progress may be an important pathogenic mechanism of Ureaplasma species.Here,we will review the association of Ureaplasma species infection and HPV infection and the relationship between TLRs and The ureaplasma lipid-associated membrane proteins.

关 键 词：解脲支原体 细菌黏附 膜蛋白质类 TOLL样受体 人乳头瘤病毒 

分 类 号：R375.3[医药卫生—病原生物学]