聚山梨酯80/Fe_3O_4复合微球的制备、特性及在靶向MRI中的应用  

Preparation,properties of Fe_3O_4/Polysorbate-80 composite microspheres and their application in MRI

作　　者：叶燕斌[1] 沈晓冬[1] 崔升[1] 仲阳[2] 林本兰[1] 

机构地区：[1]南京工业大学材料工程学院材料化学工程国家重点实验室,江苏南京210009 [2]东南大学附属南京江北人民医院,江苏南京210048

出　　处：《磁性材料及器件》2011年第6期57-62,共6页Journal of Magnetic Materials and Devices

摘　　要：采用化学共沉淀法制备出磁性纳米Fe3O4颗粒，以聚山梨酯80为改性剂制得聚山梨酯80／Fe3O4复合微球。采用透射电镜（TEM）、X射线衍射仪（XRD）、傅里叶变换红外光谱仪（FTIR）和振动样品磁强计（VSM）对其结构和性能进行了表征。结果表明：Fe3O4颗粒粒径在10～20nm，聚山梨酯80包覆在其表面。复合微球的饱和磁化强度为69．7A·m2／kg。这种复合微球具有很好的分散性和生物相容性，其注射剂作为造影剂应用在新西兰兔的脑靶向性磁共振成像上能够产生很好的T2造影效果。The magnetic Fe3O4 nanoparticles were prepared by co-precipitation method, then polysorbate-80 as modifier was coated on the surface of Fe3O4 nanoparticles to get FeaO4/p01ysorbate-80 composite microspheres. The structure and properties of Fe3O4/polysorbate280 composite microspheres were characterized by means of transmission electronmicroscope（TEM）, X-ray diffraction（XRD）, Fourier transform infrared speetrometry（FTIR） and vibrating sample magnetometer（VSM）. The results showed that the diameter of Fe3O4 nanoparticle is 10-20 nm, polysorbate-80 is well coated on the surface of Fe3O4 nanoparticles. The saturation magnetization of the composite microspheres is 69.7A·m2/kg. The composite microspheres show good dispersion and biocompatibility, and their injections as contrast agents are we｜l applied in the MRI of brain-targeted to produce very good T2 imaging effect.

关 键 词：聚山梨酯80/纳米Fe3O4复合微球 制备 特性 磁共振成像 造影剂 

分 类 号：TB383[一般工业技术—材料科学与工程] TM271[电气工程—电工理论与新技术]