游泳对载脂蛋白E敲除大鼠的脂代谢和动脉粥样硬化形成的影响  

Effect of Swimming on Lipid Metabolism and Atherogenesis in Apolipoprotein E Knock-Out Mice

作　　者：王成绩[1] 

机构地区：[1]巢湖学院体育系,安徽巢湖238000

出　　处：《宜春学院学报》2011年第12期145-147,共3页Journal of Yichun University

摘　　要：研究评价6周游泳运动对载脂蛋白E(apoE-/-)敲除的6周龄大鼠脂质代谢和动脉粥样硬化的影响。大鼠分为对照组(n=7)和运动组(n=7)。运动组大鼠进行6周递增负荷游泳运动,每周均按照第一天10分钟,每周5天(每天增加10分钟,直到连续运动1小时)。评价运动前和运动后血浆总胆固醇。处死大鼠后评价胸、腹主动脉粥样硬化的面积。体重、脂代谢两组结果相似。运动组的相关统计指数降低,表明apoE-/-大鼠游泳运动后动脉粥样硬化病变减少。但这种改变与脂肪代谢无关。This study evaluated the effects of 6 weeks of swimming on lipid metabolism, and atheroselerosis in 6 - week - old female apolipoprotein E - deficient mice （ apoE -/- ） . The mice were divided into a control group （ n = 7 ） and a exercise group （ n = 7 ） . Mice in the exercise group were required to swim 10 min· d-1, 5d · wk-1 for 6 weeks （which was increased by 10 rain · d-1 until the mice swam continuously for I hr） . Plasma total cholesterol was evaluated before and after the experiment. Atherosclerotic area of tho- racic and abdominal aorta was evaluated after euthanasia. Body weight, lipid metabolism was similar in both groups. Relative index was statistically decreased in the experimental group, thus suggesting that the apoE -/- mice that underwent the swimming exercise exhibi- ted decreased atherosclerotic lesions in the aorta. However, the decrease was not due to changes in lipid metabolism.

关 键 词：身体活动 动脉粥样硬化 脂肪代谢 

分 类 号：G804.5[文化科学—运动人体科学]