豚鼠和小鼠光变态反应性接触性皮炎模型的建立及比较  

THE ESTABLISHMENT OF THE MODELS OF PHOTOALLERGIC CONTACT DERMATITIS IN GUINEA PIGS AND MOUSE

作　　者：刘玲玲[1] 朱学骏[1] 王晓彦[2] 

机构地区：[1]北京医科大学第一医院皮肤科,100034 [2]内蒙古医学院附属医院皮肤科

出　　处：《中国现代医学杂志》2000年第1期1-2,共2页China Journal of Modern Medicine

基　　金：杨森皮肤科学教育和研究基金资助课题

摘　　要：目的 :比较两种动物作为光变态反应性接触性皮炎 (PCAD)模型各自的优势 ,以择其在临床工作中发现潜在的光敏性物质。方法 :以 6 -甲基香豆素 (6 -MC)为光敏剂分别制作豚鼠和小鼠UVA的PACD模型 ,并以外涂 6 -MC经UVB照射组作为对照。结果 :成功的建立了两种动物外涂 6 -MC并经UVA照射的PACD模型。结论 :两种动物PACD模型各占优势 。Objective:To compare respective advantages of two animals of guinea pigs and mouse as the models of photoalletgic contact dermatitis (PACD),for choosing the right animal model to discover potential photosensitive substances.Methids:The ultraviolet (UV) PACD models of guinea pigs and mouse were established by adopting 6-methylcourmarin as the photo sensitizer,the group externally covered with 6-methylcourmarin was used as the control after having received UV exposure.Results: Two kinds of PACD animal models externally covered with 6-methylcourmarin and receiving UV exposure were established successfully.Conclusions:These two kinds of PACD animal models have their own advantages respectively.We can choose the propet animal models in the manner of the practical requirements.

关 键 词：豚鼠 6-MC PACD 接触性皮炎 动物模型 

分 类 号：R758.22[医药卫生—皮肤病学与性病学] R－332[医药卫生—临床医学]