复发性外阴阴道假丝酵母菌病阴道局部IFN-γ和IgE水平测定  

THE LEVEL OF IFN-γ AND IGE IN THE VAGINAL FLUID OF RECURRENT VULVOVAGINAL CANDIDIASIS PATIENTS

作　　者：车坤兰[1] 何凤仪[1] 李锦玉[1] 佘达贤[1] 张宏英[1] 黄婵[1] 

机构地区：[1]广州医学院第二附属医院,广东广州510260

出　　处：《现代医院》2011年第12期3-4,共2页Modern Hospitals

基　　金：广东省医学科研基金项目(编号:A2009270)

摘　　要：目的测定复发性外阴阴道假丝酵母菌病(Recurrent Vulvovaginal Candidiasis,RVVC)患者阴道冲洗液中IFN-γ和IgE的浓度,探讨RVVC患者阴道局部免疫环境的改变情况。方法 ELISA法检测单纯性外阴阴道假丝酵母菌病(uncomplicated VVC)组和RVVC组患者阴道冲洗液中IFN-γ和IgE的浓度,以健康体检妇女为对照组。结果 RVVC组和单纯性VVC组患者阴道冲洗液中IFN-γ的浓度明显低于对照组(p<0.05),RVVC组较单纯性VVC组低(p<0.01)。RVVC组和单纯性VVC组患者阴道冲洗液中IgE的浓度明显高于对照组(p<0.01),RVVC组和单纯性VVC组比较无显著性差异(p>0.05)。结论 RVVC的发病可能与阴道局部免疫环境的改变有关。Objective To detect the concentration of IFN-γ and IgE in the vaginal fluid of recurrent vulvovaginal candidiasis patients,and to investigate the vaginal local immune environmental change of RVVC patients. Methods The concentration of IFN-γ and IgE in the vaginal fluid of uncomplicated VVC and RVVC patients was detected by ELISA and compared with that from normal controls. Results The concentration of IFN-γ in the vaginal fluid of uncomplicated VVC and RVVC patients was significantly lower than that in the control group（p0.05）.The concentration of IFN-γ in the vaginal fluid of RVVC group was lower than that in the uncomplicated VVC group（p0.01）.The concentration of IgE in the vaginal fluid of uncomplicated VVC and RVVC patients was obviously higher than that of the control group（p0.01）,between the RVVC group and the uncomplicated VVC group there was no significant differences（p0.05）. Conclusion The pathogenesis of RVVC may be connected with the vaginal local immune environmental change.

关 键 词：复发性外阴阴道假丝酵母菌病 干扰素-Γ 免疫球蛋白E 

分 类 号：R711.31[医药卫生—妇产科学]