1-(2-萘氧乙酰基)-4-芳杂环取代氨基脲的合成与表征  

Synthesis and Characterization of 1-(2-naphthyloxyacetyl)-4-Aromatic Heterocyclic Substituted Semicarbazides

作　　者：柴兰琴[1] 崔凯[1] 张玉丽[1] 王再蕊[1] 张永泽[1] 

机构地区：[1]兰州交通大学化学与生物工程学院,甘肃兰州730070

出　　处：《兰州交通大学学报》2011年第6期157-160,共4页Journal of Lanzhou Jiaotong University

基　　金：甘肃省自然科学基金资助项目(1107RJZA165);兰州交通大学大学生科技创新项目(DXS2011-001)

摘　　要：以芳杂环取代酸为原料,用Curtius重排的方法合成异氰酸酯,直接与2-萘氧乙酰肼作用,一锅法合成了4种1-(2-萘氧乙酰基)-4-取代芳杂环氨基脲类化合物.该方法具有原料易得、操作简便、无需分离中间体等优点.目标产物的结构经元素分析、IR及1 H NMR得到了确证.New compounds of the type of 1-（2-naphthyloxyacetyl）-4-substituted aromatic heterocyclic semicarbazides were synthesized by a series of reactions of preparing organic isocyanates by Curtius rearrangement with 2-naphthaline aryloxyacetic acid hydrazide using one-pot procedure.This method has the advantages of easy handling,high yields,easy preparation and mild reaction conditions.The structure of compounds was characterized by elemental analysis,IR and 1H NMR.

关 键 词：芳杂环 氨基脲 Curtius重排 异氰酸酯 合成 

分 类 号：O626.21[理学—有机化学]