右美托咪啶复合丙泊酚在无痛ESD中的应用  

Clinical efficacy of propofol with dexmedetomidine in endoscopic submucosal dissection

作　　者：徐钢[1] 陆颖[1] 黄礼兵[1] 崔苏扬[1] 

机构地区：[1]南京中医药大学附属医院,南京210029

出　　处：《实用药物与临床》2011年第6期470-471,共2页Practical Pharmacy and Clinical Remedies

摘　　要：目的观察右美托咪啶复合丙泊酚在无痛内镜黏膜下剥离术(ESD)中应用的麻醉效果及安全性。方法 ASA I～Ⅱ级行肠道黏膜下剥离术(ESD)患者40例,随机分为2组,丙泊酚麻醉组(A组),右美托咪啶复合丙泊酚麻醉组(B组);记录各时间点HR、SpO2、MAP、RR,手术时间,苏醒时间,麻醉后不良反应及并发症,患者苏醒即刻腹痛(VAS)。结果两组RR、SpO2、手术时间、苏醒时间差异无统计学意义,诱导入睡后,与A组相比,B组MAP升高、HR下降(P<0.05),丙泊酚总用量、不良反应发生率B组均少于A组(P<0.05),VAS评分B组低于A组。结论右美托咪啶复合丙泊酚用于无痛ESD,是一种安全有效的麻醉方法。Objective To evaluate the effect and safety of propofol with dexmedetomidine in endoscopic submucosal dissection（ESD）.Methods Forty ASA physical status of Ⅰ or Ⅱ patients undergoing ESD were randomly divided into two groups：Group A（20 cases）was given propofol alone;Group B（20 cases）was given intravenously dexmedetomidine followed by propofol.The following indexes were recorded：HR,SpO2,MAP,RR at each time point before anesthesia and under operation,the time of operation and palinesthesia,adverse reaction and complication after anesthesia,and VAS scores of hypogastralgia.Results There was no significant difference in RR,SpO2,the time of operation and palinesthesia between the 2 groups.The MAP after anesthesia in group B was higher than that of group A（P0.05）;HR,the percentage of adverse reaction and complication after anesthesia in group B were lower than those of group A（P0.05）.The VAS scores at immediate time of palinesthesia in group B was lower than that of group A（P0.05）.Conclusion The anesthetic effect of dexmedetomidine combined with propofol for patients undergoing ESD is satisfactory and safe.

关 键 词：右美托咪啶 丙泊酚 内镜黏膜下剥离术 

分 类 号：R614[医药卫生—麻醉学]