注射用氯诺昔康在不同pH值氯化钠注射液中的稳定性考察  

Stability of lornoxicam in 0.9% sodium chloride injection with different pH values

作　　者：方宝霞[1] 丁洁[2] 陈富超[1] 胡敏[1] 李鹏[1] 

机构地区：[1]湖北医药学院附属东风医院药学部,湖北十堰442008 [2]湖北医药学院附属东风医院麻醉科,湖北十堰442008

出　　处：《实用药物与临床》2011年第6期494-495,共2页Practical Pharmacy and Clinical Remedies

基　　金：十堰市科学技术研究与开发计划项目(2010st45)

摘　　要：目的考察注射用氯诺昔康在不同pH值(4.5～7.0)0.9%氯化钠注射液中的稳定性。方法采用高效液相色谱法测定配伍液中氯诺昔康的含量,考察室温条件下氯诺昔康在不同pH值0.9%氯化钠注射液中8 h含量变化,并观察和检测配伍液的外观及pH值变化。结果注射用氯诺昔康在不同pH值0.9%氯化钠注射液中的含量、外观与pH值均无明显变化。结论注射用氯诺昔康在不同pH值0.9%氯化钠注射液中8 h均保持稳定。Objective To study the stability of lornoxicam in 0.9% sodium chloride injection with different pH values（4.5~7.0）.Methods The changes of the contents of lornoxicam were determined by HPLC at room temperature,the pH value and appearance of the solution were observed within 8 h in 0.9% sodium chloride injection with different pH values.Results The content,appearance and pH values of lornoxicam in 0.9% sodium chloride injection with different pH values had no significant changes.Conclusion The mixture of lornoxicam in 0.9% sodium chloride injection with different pH values is stable within 8 h.

关 键 词：氯诺昔康 PH值 配伍 稳定性 HPLC 

分 类 号：R942[医药卫生—药剂学]