平糖方对高脂饮食大鼠胰岛素敏感性的影响  

Impacts of Pingtang Formula on Insulin Sensitivity for theRats with High-fat Feeding

作　　者：苏伟娟[1] 刘长勤[2] 李学军[2] 杨叔禹[2] 

机构地区：[1]福建中医药大学,福建福州350108 [2]厦门大学附属第一医院厦门市糖尿病研究所,福建厦门361003

出　　处：《世界中西医结合杂志》2011年第12期1032-1034,1051,共4页World Journal of Integrated Traditional and Western Medicine

摘　　要：目的研究以泽泻方加减组成的平糖方对改善高脂喂养诱导的胰岛素抵抗大鼠胰岛素敏感性的影响。方法将建模成功的高脂大鼠,随机分为高脂模型组和中药组,以正常大鼠为对照组,观察平糖方在提高胰岛素敏感性、降低血糖、调节血脂紊乱等方面的作用。结果平糖方治疗4周后,口服葡萄糖耐量试验(OGTT)中,中药组60 min、120 min血糖较高脂模型组显著降低,差异有统计学意义(P<0.05),60 min血糖甚至显著低于正常饮食组,差异有统计学意义(P<0.05);胰岛素耐量试验(ITT)同样也显示,中药组在注射等剂量的胰岛素后,60 min的血糖显著低于高脂模型组和正常饮食组,差异均有统计学意义(P<0.05);另一方面,中药组在治疗后TG也均显著低于高脂模型组和正常饮食组,差异均有统计学意义(P<0.05)。结论健脾益肾、化痰祛瘀的中药复方对改善高脂喂养大鼠的胰岛素敏感性具有积极作用,并一定程度上纠正了高脂大鼠糖脂代谢紊乱状态。Objective To study the impacts of pingtang formula（modified rhizome alismatis formula）on insulin sensitivity of the rats with insulin resistance induced by high-fat feeding.Methods The successfully-modeled high-fat rats were randomized into a high-fat model group and a Chinese herbal medicine group.Additionally,the healthy rats were selected in a control group.The effects of pingtang formula were observed on improving insulin sensitivity,reducing blood glucose and adjusting blood lipid.Results After treated for 4 weeks with pingtang formula,in OGTT test,in Chinese herbal medicine group,the levels of blood glucose in 60min and 120min were reduced significantly as compared with high-fat model group,indicating statistical significant difference（P0.05）.The level of blood glucose in 60min was significantly lower than that in normal feeding group,indicating statistical significant difference（P0.05）.The same results were shown in ITT test.After injecting insulin of the same dosage,in Chinese herbal medicine group the level of blood glucose in 60min was lower significantly than that in high-fat model group and normal feeding group,indicating statistical significant difference（P0.05）.On the other hand,after treatment,TG in Chinese herbal medicine group was lower significantly than that in high-fat model group and normal feeding group,indicating statistical significant difference（P0.05）.Conclusion The compound Chinese herbal medicine for strengthening the spleen,benefiting the kidney,resolving phlegm and removing stasis has an positive effect on improving insulin sensitivity for the rats with high-fat feeding and rectifying to a certain extent the glucose-lipid metabolic disturbance for high-fat rats.

关 键 词：平糖方 胰岛素抵抗 血糖 血脂 大鼠 

分 类 号：R285.5[医药卫生—中药学] R587[医药卫生—中医学]