苦碟子注射液联合甲钴胺治疗糖尿病周围神经病变疗效观察  

Efficacy Observation of Diabetic Peripheral Neuropathy Treated with Kudiezi Injection and Mecobalamin

作　　者：万继峰[1] 陆尤[1] 郝丽梅[1] 任歆[1] 徐云燕[1] 常素杰[1] 周卫东[1] 

机构地区：[1]北京煤炭总医院,北京100028

出　　处：《世界中西医结合杂志》2011年第12期1049-1051,共3页World Journal of Integrated Traditional and Western Medicine

摘　　要：目的探讨苦碟子联合甲钴胺治疗糖尿病周围神经病变(DPN)的疗效和客观判断疗效的方法。方法选择糖尿病周围神经病变患者152例,随机分成治疗组和对照组,对照组给予降糖及甲钴胺治疗,治疗组在对照组治疗基础上加用苦碟子注射液,疗程均为4周;在治疗前后分别测定神经传导速度(NCV)。结果经过4周治疗后,两组正中神经和胫神经的潜伏期均缩短,波幅均增高,传导速度均增快,与本组治疗前比较,差异均有统计学意义(P<0.05);治疗后两组间比较,治疗组各神经的潜伏期缩短更明显,波幅增加更增高,传导速度更快,与对照组比较,差异均有统计学意义(P<0.05)。结论苦碟子联合甲钴胺治疗糖尿病周围神经病疗效确切,神经传导速度(NCV)明显改善。Objective To explore the efficacy on diabetic peripheral neuropathy（DPN）treated with kudiezi injection and mecobalamin and judge objectively the efficacy assessment.Methods 152 cases of DNP were selected and randomized into a treatment group and a control group.In control group,mecobalamin was administered for down-regulating glucose.In treatment group,on the basis of the treatment as control group,kudiezi injection was supplemented.The duration of treatment was 4 weeks.Before and after treatment in two groups,the nerve conduction velocity（NCV）was detected separately.Results After 4-week treatment,the latent period of median nerve and tibial nerve was shortened,the wave amplitude increased and conduction velocity was accelerated,which was different statistically as compared with those before treatment in the same group（P0.05）.In intra-group comparison after treatment,the latent period of each nerve in treatment group was much obviously shortened,the wave amplitude much increased and the conduction velocity was greatly accelerated,which was different statistically as compared with control group（P0.05）.Conclusion The combined therapy with kudiezi injection and mecobalamin achieves a definite efficacy on DPN and obviously improves NCV.

关 键 词：苦碟子注射液 甲钴胺 糖尿病周围神经病变(DPN) 神经传导速度(NCV) 

分 类 号：R285.6[医药卫生—中药学] R587.2[医药卫生—中医学]