急性缺血性冠状动脉综合征患者血浆D-二聚体检测的临床意义  

Clinic significance of plasma D-dimer in patients with acute ischemic coronary syndrome

作　　者：陈书艳[1] 张建军[2] 王淑香[1] 朱玮琪[1] 赵美华[1] 吕宝经[1] 荣烨之[1] 

机构地区：[1]上海第二医科大学附属新华医院心内科,上海200092 [2]上海市第一人民医院心内科

出　　处：《中国急救医学》2000年第1期26-27,共2页Chinese Journal of Critical Care Medicine

摘　　要：目的　观察急性缺血性冠状动脉综合征患者血浆D-二聚体含量的变化并探讨其临床意义。方法　采用ELLSA双抗体夹心法检测急性心肌梗死(AMI)组(21例)、不稳定性心绞痛(UAP)组(19例)、稳定性心绞痛(SAP)组(24例)、对照组(20例)血浆D-二聚体含量。结果　AMI组和UAP组血浆D-二聚体均高于对照组和SAP组(P<0001;P<0001;P<005;P<005),其中AMI组较UAP组升高更为明显(P<001);SAP组与对照组比较无明显差异(P>005)。结论　血浆D-二聚体的含量可作为急性心肌梗死早期诊断的参考指标及稳定性心绞痛和不稳定性心绞痛鉴别的参考指标。Objective To observe the changes of plasma D-dimer in patients with acute ischemic coronary syndrome and explore the clinic significance.Methods The plasma D-dimer content were determined by ELISA in 21 acute myocardial infarction(AMI group),19 unstable angina pectoris(UAP group),24 stable angina pectoris(SAP group)and 20 normal(control group).Result The plasma D-dimer content in AMI group and UAP group is higher than that in SAP group and control group( P <0 001; P <0 001; P <0 05; P <0 05).The plasma D-dimer content in AMI group is significantly higher than that in UAP group( P <0 01).However,there was no significantly difference between SAP group and control group( P >0 05).Conclusion Plasma D-dimer content may be considered as an marker for the early diagnosis of AMI and has some value in distinction UAP with SAP. [

关 键 词：缺血性 冠状动脉综合征 D-二聚体 诊断 

分 类 号：R541.4[医药卫生—心血管疾病] R446.61[医药卫生—内科学]