门冬胰岛素30注射液强化治疗Ⅱ型糖尿病的临床观察  

Clinical Observation of Insulin Aspart 30 Injection Intensive Treatment on Type Ⅱ Diabetes

作　　者：杜兴旭[1] 曹艳华 王春梅[3] 王云东 

机构地区：[1]北华大学附属医院,吉林吉林132011 [2]解放军第222医院,吉林吉林132002 [3]北华大学药学院,吉林吉林132013 [4]吉林化学工业集团股份有限公司总医院,吉林吉林132010

出　　处：《北华大学学报（自然科学版）》2011年第6期683-685,共3页Journal of Beihua University（Natural Science）

摘　　要：目的观察门冬胰岛素30（诺和锐30）注射液强化治疗Ⅱ型糖尿病的效果.方法Ⅱ型糖尿病患者86例,给予生活方式干预,包括健康教育,低热量、低脂肪饮食,中等体力活动,戒烟、限酒,血压高者给予降压等,血脂异常者给予调脂.治疗组给予诺和锐30注射液3餐前皮注（根据血糖监测结果调整胰岛素剂量）,对照组给予诺和灵30R笔芯,早、晚餐前30 min皮注.观察6个月,观察治疗前后患者的FBG、2hPBG、HbA1c及低血糖发生率的变化.结果Ⅱ型糖尿病患者用诺和锐30强化治疗后,FBG、2hPBG、HbA1c等指标均好于对照组,低血糖发生率较对照组减少,P〈0.01,经比较有统计学意义.结论对Ⅱ型糖尿病患者应用诺和锐30强化治疗,血糖平稳,低血糖发生率减低,疗效肯定.Objective To observe effect of insulin aspart 30（novorapid） injection intensive treatment on type Ⅱ diabetes.Method 86 patients with type Ⅱ diabetes were given the lifestyle interventions,including health education,low-calorie and low fat diet,moderate physical activity,giving up smoking and limiting alcohol.Meanwhile,the patients with hypertension and（or） dyslipidemia were given antihypertensive therapy and（or） regulation of blood lipid respectively.86 patients were randomly divided into two groups,the treatment group was administered novorapid 30 injection in subcutaneous injection before 3 meals（insulin dosage was adjusted based on blood glucose monitoring results）,and the control group was administered novolin 30 in subcutaneous injection before 30 minutes breakfast and dinner for six months.Fasting blood glucose（FBS）,2-hour postprandial blood glucose（2hPBG）,HbA1c and the incidence of hypoglycemia were monitored before and after the treatment.Results FBG,2hPBG,HbA1c in type Ⅱ diabetic patients treated with novorapid 30 were decreased more significantly compared with those of patients treated with novolin 30.The incidence of hypoglycemia was lower in the treatment group compared with that in the control group（P0.05）.Conclusion Patients with type Ⅱ diabetes given novorapid 30 intensive treatment showed a stable blood glucose and a reduced incidence of hypoglycemia.The novorapid 30 has a good therapeutic effect on type Ⅱ diabetes.

关 键 词：门冬胰岛素30注射液 Ⅱ型糖尿病 诺和灵30R笔芯 

分 类 号：R587[医药卫生—内分泌]